20(S),24(S)-Dihydroxydammar-25-en-3-one
20(S),24(S)-Dihydroxydammar-25-en-3-one (compound 19) is a kind of triterpene. 20(S),24(S)-Dihydroxydammar-25-en-3-one can be isolated from the floral spikes of Betula platyphylla var. 20(S),24(S)-Dihydroxydammar-25-en-3-one has cytotoxicity against Human Cancer Cell Lines.
For research use only. We do not sell to patients.
- CAS No.: 75069-59-9
- Formula: C30H50O3
- Molecular Weight:458.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| COLO 205 | IC50 |
58.8 μM
Compound: 19
|
Cytotoxicity against human COLON205 cells after 48 hrs by MTT assay
Cytotoxicity against human COLON205 cells after 48 hrs by MTT assay
|
[PMID: 17346076] |
| K562 | IC50 |
40.2 μM
Compound: 19
|
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
|
[PMID: 17346076] |
| K562/Adr | IC50 |
35.9 μM
Compound: 19
|
Cytotoxicity against human doxorubicin-resistant K562/Adr cells after 48 hrs by MTT assay
Cytotoxicity against human doxorubicin-resistant K562/Adr cells after 48 hrs by MTT assay
|
[PMID: 17346076] |
| K562/Adr | IC50 |
50.4 μM
Compound: 19
|
Cytotoxicity against human doxorubicin-resistant K562/Adr cells in presence of 1 uM doxorubicin after 48 hrs by MTT assay
Cytotoxicity against human doxorubicin-resistant K562/Adr cells in presence of 1 uM doxorubicin after 48 hrs by MTT assay
|
[PMID: 17346076] |
| KB | IC50 |
70.2 μM
Compound: 19
|
Cytotoxicity against human KB cells after 48 hrs by MTT assay
Cytotoxicity against human KB cells after 48 hrs by MTT assay
|
[PMID: 17346076] |
| MCF7 | IC50 |
73.1 μM
Compound: 19
|
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
|
[PMID: 17346076] |
Chemical Information
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CAS No. 75069-59-9
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Molecular Weight 458.72
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Formula C30H50O3
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SMILES
CC1(C)C(CC[C@]2(C)[C@@]3([H])CC[C@]4([H])[C@]([C@@](C)(O)CC[C@H](O)C(C)=C)([H])CC[C@](C)4[C@@](C)3CC[C@@]12[H])=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)