Isodispar B
Isodispar B is an anticancer agent that inhibits the proliferation of nasopharyngeal carcinoma and breast cancer cells and induces cell apoptosis. Isodispar B is cytotoxic to a wide range of cancer cell lines.
For research use only. We do not sell to patients.
- CAS No.: 98192-64-4
- Formula: C20H18O5
- Molecular Weight:338.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KB | IC50 |
4 μg/mL
Compound: 23
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Cytotoxicity against human KB cells assessed as inhibition of cell growth incubated for 72 hrs by neutral red dye based colorimetric assay
Cytotoxicity against human KB cells assessed as inhibition of cell growth incubated for 72 hrs by neutral red dye based colorimetric assay
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[PMID: 27494166] |
| MCF7 | GI50 |
1.5 μg/mL
Compound: 13
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Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
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[PMID: 15787438] |
| NCI-H460 | GI50 |
1.9 μg/mL
Compound: 13
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Cytotoxicity against human H460 cells
Cytotoxicity against human H460 cells
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[PMID: 15787438] |
| SF-268 | GI50 |
1.8 μg/mL
Compound: 13
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Cytotoxicity against human SF268 cells
Cytotoxicity against human SF268 cells
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[PMID: 15787438] |
Isodispar B (compound 1) (0-100 μM; 72 h) exerts a broad spectrum of anti-cancer activity to inhibit cell proliferation with IC50s of 3.84-56.73 μM[1].
Isodispar B (1 μM and 10 μM; 3 d) induces apoptosis on nasopharyngeal cancer cells (TW01, CNE1, HK1, and SUNE1)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Nasopharyngeal cancer cells (TW01, CNE1, HK1, and SUNE1) and noncancerous nasopharyngeal cells (NP460)
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Concentration:0-100 μM
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Incubation Time:72 hours
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Result:Showed cytotoxicity and inhibited cell viability with IC50s of 3.84 μM (SUNE1), 11.49 μM (TW01), 9.74 μM (CNE1), 5.58 μM (HK1), 56.73 μM (HCC38), 52.69 μM (MDA-MB-231), 52.75 μM (MDA-ME-468), and 54.85 μM (SKBR3), respectively.
Chemical Information
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CAS No. 98192-64-4
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Molecular Weight 338.35
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Formula C20H18O5
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SMILES
O=C1C=C(C2=CC=CC=C2)C3=C(O)C=C(O)C(C(CC(C)C)=O)=C3O1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Isodispar B Related Classifications
HY-N10304 Related Classifications
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