2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. N-Deacetyl-N-formylcolchicine

N-Deacetyl-N-formylcolchicine  (Synonyms: N-Formyl-N-deacetylcolchicine)

Cat. No.: HY-Z8644
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N-Deacetyl-N-formylcolchicine (N-Formyl-N-deacetylcolchicine, Compound 11) is a selective inhibitor targeting the colchicine-binding site of tubulin. N-Deacetyl-N-formylcolchicine shows antiproliferative activity against various cancer cell lines with IC50 values of 32.61-100.28 nM. N-Deacetyl-N-formylcolchicine inhibits microtubule polymerization to block cell division, induces cancer cell apoptosis and suppresses migration. N-Deacetyl-N-formylcolchicine is promising for research of cancers such as lung cancer and various solid tumors.

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N-Deacetyl-N-formylcolchicine

N-Deacetyl-N-formylcolchicine Chemical Structure

CAS No. : 7411-12-3

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Description

N-Deacetyl-N-formylcolchicine (N-Formyl-N-deacetylcolchicine, Compound 11) is a selective inhibitor targeting the colchicine-binding site of tubulin. N-Deacetyl-N-formylcolchicine shows antiproliferative activity against various cancer cell lines with IC50 values of 32.61-100.28 nM. N-Deacetyl-N-formylcolchicine inhibits microtubule polymerization to block cell division, induces cancer cell apoptosis and suppresses migration. N-Deacetyl-N-formylcolchicine is promising for research of cancers such as lung cancer and various solid tumors[1].

Masse moléculaire

385.41

Formule

C21H23NO6
CAS No.
SMILES

COC1=C2C(C([C@H](CCC2=CC(OC)=C1OC)NC=O)=C3)=CC=C(OC)C3=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

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N-Deacetyl-N-formylcolchicine Related Classifications

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Keywords:

N-Deacetyl-N-formylcolchicine7411-12-3N-Formyl-N-deacetylcolchicineMicrotubule/TubulinApoptosisTubulincancer cell linescancersInhibitorinhibitorinhibit

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