7411-12-3
Chemical Structure
N-Deacetyl-N-formylcolchicine
Synonym(s): N-Formyl-N-deacetylcolchicine
- CAS No.: 7411-12-3
- Formula:C21H23NO6
- Molecular Weight:385.41
IUPAC Name: (S)-N-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)formamide
InChIKey: HDSXDWASQCHADG-HNNXBMFYSA-N
SMILES: COC1=C2C(C([C@H](CCC2=CC(OC)=C1OC)NC=O)=C3)=CC=C(OC)C3=O
Biological Activity: N-Deacetyl-N-formylcolchicine (N-Formyl-N-deacetylcolchicine, Compound 11) is a selective inhibitor targeting the colchicine-binding site of tubulin. N-Deacetyl-N-formylcolchicine shows antiproliferative activity against various cancer cell lines with IC50 values of 32.61-100.28 nM. N-Deacetyl-N-formylcolchicine inhibits microtubule polymerization to block cell division, induces cancer cell apoptosis and suppresses migration. N-Deacetyl-N-formylcolchicine is promising for research of cancers such as lung cancer and various solid tumors[1].
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N-Deacetyl-N-formylcolchicine | N-Deacetyl-N-formylcolchicine (N-Formyl-N-deacetylcolchicine, Compound 11) is a selective inhibitor targeting the colchicine-binding site of tubulin. N-Deacetyl-N-formylcolchicine shows antiproliferative activity against various cancer cell lines with IC50 values of 32.61-100.28 nM. N-Deacetyl-N-formylcolchicine inhibits microtubule polymerization to block cell division, induces cancer cell apoptosis and suppresses migration. N-Deacetyl-N-formylcolchicine is promising for research of cancers such as lung cancer and various solid tumors. | |||||||||||||||||||||
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Keywords
