1. Apoptosis
    Epigenetics
  2. Apoptosis
    Histone Methyltransferase
  3. NSC745885

NSC745885 

Cat. No.: HY-119198 Purity: >98.0%
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NSC745885 an effective anti-tumor agent, shows selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 provides possibilities for the study of advanced bladder and oral squamous cell carcinoma (OSCC) cancers.

For research use only. We do not sell to patients.

NSC745885 Chemical Structure

NSC745885 Chemical Structure

CAS No. : 4219-52-7

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Description

NSC745885 an effective anti-tumor agent, shows selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 provides possibilities for the study of advanced bladder and oral squamous cell carcinoma (OSCC) cancers[1][2].

IC50 & Target[2]

EZH2

 

In Vitro

NSC745885 (0.5-4 μM; 24, 48 or 72 hours) has a growth inhibitory or death-promoting effect on the SAS cells, it significantly decreases the densities of cultured cells when compared with untreated cells. The IC50 of NSC745885 is 0.85 μM after 72 hours’ treatment[1].
NSC745885 (0.5-4 μM; 24 hours) increases annexin V positive cells in a dose-dependent manner, and the differences appears as a dose-dependent manner[1].
NSC745885 (0.5-2 μM; 24 or 48 hours) decreases XIAP protein levels and increases protein levels both as a dose-dependent manner in SAS cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SAS cells is obtained from a poorly differentiated human squamous cell carcinoma
Concentration: 0.5 μM, 1 μM, 1.5 μM, 2 μM, 4 μM
Incubation Time: 24, 48, or 72 hours
Result: Decreases SAS cells growth as a time and dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: SAS cells is obtained from a poorly differentiated human squamous cell carcinoma
Concentration: 0.5 μM, 1 μM, 1.5 μM, 2 μM, 4 μM
Incubation Time: 24 hours
Result: Decreases SAS cells growth as a time and dose-dependent manner.

Western Blot Analysis[1]

Cell Line: SAS cells is obtained from a poorly differentiated human squamous cell carcinoma
Concentration: 0.5 μM, 1 μM, 1.5 μM, 2 μM
Incubation Time: 24 or 48 hours
Result: Increased cleaved caspase-3 expression and decreased XIAP expression.
In Vivo

NSC745885 (intraperitoneal injection; 2 mg/kg; once daily; 10 days) treatment significantly reduces tumor size when compared with the vehicle control, and exhibits a higher safety than doxorubicin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old NOD/SCID (NOD.CB17 Prkdcscid/J) mice[1]
Dosage: 2 mg/kg
Administration: Intraperitoneal injection; 2 mg/kg; once daily; 10 days
Result: Inhibited engrafted tumors growth in vivo.
Molecular Weight

266.27

Formula

C₁₄H₆N₂O₂S

CAS No.

4219-52-7

SMILES

O=C(C1=C(C2=O)C3=NSN=C3C=C1)C4=C2C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

*NSC745885 is usually formulated as a suspension.

References
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Keywords:

NSC745885NSC 745885NSC-745885ApoptosisHistone MethyltransferaseChemotherapysquamouscellcarcinomaadvancedbladdercancerEZH2multiple-drugresistanceInhibitorinhibitorinhibit

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NSC745885
Cat. No.:
HY-119198
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