4219-52-7
4219-52-7
Chemical Structure
NSC745885
- CAS No.: 4219-52-7
- Formula:C14H6N2O2S
- Molecular Weight:266.27
IUPAC Name: anthra[1,2-c][1,2,5]thiadiazole-6,11-dione
InChIKey: SJPXIVLTCBBWKT-UHFFFAOYSA-N
SMILES: O=C(C1=C(C2=O)C3=NSN=C3C=C1)C4=C2C=CC=C4
Biological Activity: NSC745885 an effective anti-tumor agent, shows selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 provides possibilities for the study of advanced bladder and oral squamous cell carcinoma (OSCC) cancers[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NSC745885 | 98.0% | NSC745885 an effective anti-tumor agent, shows selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 provides possibilities for the study of advanced bladder and oral squamous cell carcinoma (OSCC) cancers. | ||||||||||||||||||||
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References
- [1]. Chen YW, et al.A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo.PLoS One. 2014 Aug 15;9(8):e104703. [Content Brief]
- [2]. Tang SH, et al. Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo.Oncotarget. 2014 Nov 15;5(21):10342-55. [Content Brief]
