BAY-958
BAY-958 is a potent PTEFb/CDK9 inhibitor with high selectivity demonstrated, particularly within the CDK family. BAY-958 shows strong antiproliferative activity against cancer cell lines such as HeLa and MOLM-13. BAY-958 exhibits good metabolic stability. BAY-958 effectively inhibits tumor growth in mouse xenograft models without significant toxicity.
For research use only. We do not sell to patients.
- CAS No.: 1335490-39-5
- Formula: C17H16FN5O3S
- Molecular Weight:389.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
1 μM
Compound: 40
|
Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining method
Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining method
|
[PMID: 32866383] |
| HeLa | IC50 |
1 μM
Compound: 49; BAY-958
|
Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining assay
Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining assay
|
[PMID: 32870008] |
| MOLM-13 | IC50 |
280 nM
Compound: 40
|
Antiproliferative activity against human MOLM-13 cells incubated for 96 hrs by crystal violet staining method
Antiproliferative activity against human MOLM-13 cells incubated for 96 hrs by crystal violet staining method
|
[PMID: 32866383] |
| MOLM-13 | IC50 |
280 nM
Compound: 49; BAY-958
|
Antiproliferative activity against human MOLM-13 cells incubated for 96 hrs by crystal violet staining assay
Antiproliferative activity against human MOLM-13 cells incubated for 96 hrs by crystal violet staining assay
|
[PMID: 32870008] |
Chemical Information
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CAS No. 1335490-39-5
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Molecular Weight 389.40
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Formula C17H16FN5O3S
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SMILES
O=S(CC1=CC=CC(NC2=NC(C3=CC=C(F)C=C3OC)=NC=N2)=C1)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)