2. PROTAC Vitamin D Related/Nuclear Receptor
  3. PROTACs Androgen Receptor
  4. ARD-2051

ARD-2051 is a potent and orally active androgen receptor (AR) proteolysis-targeting chimera degrader. ARD-2051 achieves DC50 values of 0.6 nM for AR protein degradation in both the LNCaP and VCaP prostate cancer cell lines. ARD-2051 can be used for the research of prostate cancer.

For research use only. We do not sell to patients.

ARD-2051 Chemical Structure

ARD-2051 Chemical Structure

CAS No. : 2632305-17-8

Size Price Stock Quantity
1 mg USD 560 In-stock
5 mg USD 1400 In-stock
10 mg USD 2240 In-stock
25 mg USD 4485 In-stock
50 mg USD 7180 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

ARD-2051 is a potent and orally active androgen receptor (AR) proteolysis-targeting chimera degrader. ARD-2051 achieves DC50 values of 0.6 nM for AR protein degradation in both the LNCaP and VCaP prostate cancer cell lines. ARD-2051 can be used for the research of prostate cancer[1].

IC50 & Target

DC50: 0.6 nM (AR protein degradation)[1]
Molecular Weight

789.32

Formula

C43H45ClN8O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C2C=CC(N3CC(N4CCN(C(C5=CC=C(C=C5)N6CCC7(CC6)CN([C@H](C7)C)C8=CC(Cl)=C(C=C8)C#N)=O)CC4)C3)=C1)N(C2=O)C9C(NC(CC9)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (31.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2669 mL 6.3346 mL 12.6691 mL
5 mM 0.2534 mL 1.2669 mL 2.5338 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2669 mL 6.3346 mL 12.6691 mL 31.6728 mL
5 mM 0.2534 mL 1.2669 mL 2.5338 mL 6.3346 mL
10 mM 0.1267 mL 0.6335 mL 1.2669 mL 3.1673 mL
15 mM 0.0845 mL 0.4223 mL 0.8446 mL 2.1115 mL
20 mM 0.0633 mL 0.3167 mL 0.6335 mL 1.5836 mL
25 mM 0.0507 mL 0.2534 mL 0.5068 mL 1.2669 mL
30 mM 0.0422 mL 0.2112 mL 0.4223 mL 1.0558 mL
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ARD-2051 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARD-20512632305-17-8ARD2051ARD 2051PROTACsAndrogen Receptororalandrogen receptor (AR)LNCaP cellVCaP cellprostate cancerInhibitorinhibitorinhibit

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