1. Metabolic Enzyme/Protease
    Antibody-drug Conjugate/ADC Related
    Apoptosis
  2. Mitochondrial Metabolism
    ADC Cytotoxin
    Apoptosis
  3. Mensacarcin

Mensacarcin 

Cat. No.: HY-122534
Handling Instructions

Mensacarcin, a highly complex polyketide, strongly inhibits cell growth universally in cancer cell lines and potently induces apoptosis in melanoma cells. Mensacarcin targets to mitochondria, affects energy metabolism in mitochondria, and activates caspase-dependent apoptotic pathways. Mensacarcin, an antibiotic, can be used as a cytotoxic component of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Mensacarcin Chemical Structure

Mensacarcin Chemical Structure

CAS No. : 808750-39-2

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Description

Mensacarcin, a highly complex polyketide, strongly inhibits cell growth universally in cancer cell lines and potently induces apoptosis in melanoma cells. Mensacarcin targets to mitochondria, affects energy metabolism in mitochondria, and activates caspase-dependent apoptotic pathways. Mensacarcin, an antibiotic, can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1][2].

IC50 & Target[1]

Traditional Cytotoxic Agents

 

In Vitro

Mensacarcin (0-100 μM; 24 hours) exhibits general cytostatic but type-specific cytotoxic effects for melanoma cells[1].
Mensacarcin (2-50 μM; 15 hours) induces rapid apoptotic cell death in melanoma cells[1].
Mensacarcin exhibits potent cytostatic properties (mean of 50% growth inhibition=0.2 μM) in almost all cell lines of the National Cancer Institute (NCI)-60 cell line screen and relatively selective cytotoxicity against melanoma cells. Mensacarcin is a highly oxygenated polyketide that was first isolated from soil-dwelling Streptomyces bacteria. Mensacarcin impairs mitochondrial function in melanoma cells[1].

Cell Viability Assay[1]

Cell Line: SK-Mel-28 and SK-Mel-5 melanoma cells, HCT-116 colon cancer cells
Concentration: 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 24 hours
Result: Induced concentration- and time-dependent cell death in the two tested melanoma cell lines. HCT-116 colon carcinoma cells were strongly inhibited.

Western Blot Analysis[1]

Cell Line: SK-Mel-28, SK-Mel-5 cells
Concentration: 2, 10, 50 μM
Incubation Time: 15 hours
Result: Induced the formation of 89-kDa PARP-1 fragments as well as caspase-3 activation in SK-Mel-28 and SK-Mel-5 beginning between 6 and 15 h after exposure.
Molecular Weight

420.41

Formula

C₂₁H₂₄O₉

CAS No.

808750-39-2

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Keywords:

MensacarcinMitochondrial MetabolismADC CytotoxinApoptosiscancermelanomacellmitochondriacaspaseantibioticcytotoxicPARP-1Inhibitorinhibitorinhibit

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Mensacarcin
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