EGFR-IN-53
EGFR-IN-53 (Compound 7) is a potent EGFR inhibitor with an IC50 of 8.264 µM. EGFR-IN-53 shows cytotoxic activity against cancer cell lines.
For research use only. We do not sell to patients.
- CAS No.: 2418549-33-2
- Formula: C14H13N3O2S
- Molecular Weight:287.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
|
EGFR 8.264 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
1.11 μM
Compound: 7
|
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 32361329] |
| HepG2 | IC50 |
1.74 μM
Compound: 7
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 32361329] |
| MCF7 | IC50 |
7 μM
Compound: 7
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 32361329] |
| WI-38 | IC50 |
271 μM
Compound: 7
|
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 32361329] |
Chemical Information
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CAS No. 2418549-33-2
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Molecular Weight 287.34
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Formula C14H13N3O2S
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SMILES
S=C(NC1=CC=C2OCOC2=C1)NNC3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)