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Cat. No.: HY-143295

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Pim-1 kinase inhibitor 1

Pim-1 kinase inhibitor 1 is a Pim-1 kinase inhibitor with an IC₅₀ of 0.11 μM for Pim-1 kinase. Pim-1 kinase inhibitor 1 shows anticancer activity to several cancer cell lines by promotes cell apoptosis. Pim-1 kinase inhibitor 1 can be used for the research of cancer.

For research use only. We do not sell to patients.

CAS No.: 2803505-57-7
Formula: C₁₉H₁₃N₃O₃
Molecular Weight:331.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Pim-1 kinase inhibitor 1 Chemical Structure

CAS No.: 2803505-57-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

IC50: 0.11 μM (Pim-1 kinase), 10.93 μM (MCF-7), 4.91 μM (CACO), 7.01 μM (HepG-2), 3.41 μM (HCT-116), 27.181 μM (WI-38)^[1]

All Pim Isoforms :

In Vitro

Pim-1 kinase inhibitor 1 (0-200 μM; 24 h) shows vitro cytotoxic activity to several cancer cells and affects cell apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

MCF-7, CACO, HepG-2, HCT-116 and WI-38 cells
Concentration:

0-200 μM
Incubation Time:

24 hours
Result:

Exhibited vitro cytotoxic activity to MCF-7, CACO, HepG-2, HCT-116 and WI-38 cell lines with IC₅₀s of 10.93, 4.91, 7.01, 3.41 and 27.181 μM, respectively. Promoted apoptosis by increasing Casp-3, BAX and Bcl-2 concentration to achieve anti-cancer activity.

Chemical Information

CAS No. 2803505-57-7
Molecular Weight 331.32
Formula C₁₉H₁₃N₃O₃
SMILES

N#C/C(C(NC1=CC=C(C=C1)O)=O)=C\C2=CC3=CC=CC=C3N=C2O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. A. Ammar, et al. Carboxamide appended quinoline moieties as potential anti-proliferative agents, apoptotic inducers and Pim-1 kinase inhibitors. 2021.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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