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Cat. No.: HY-176058

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HDAC6-IN-57

HDAC6-IN-57 (compound 9c) is an HDAC6 inhibitor with an IC₅₀ value of 7 nM. HDAC6-IN-57 inhibits 60 cancer cell lines with a mean GI₅₀ of 2.64 μM while exhibiting significantly lower cytotoxicity towards non-tumor cell lines.

For research use only. We do not sell to patients.

Formula: C₂₇H₂₉BrN₄O₄
Molecular Weight:553.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

HDAC6-IN-57 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All HDAC Isoforms :

Chemical Information

Molecular Weight 553.45
Formula C₂₇H₂₉BrN₄O₄
SMILES

O=C(NO)CCCCCCN1CC(N2[C@H](C1=O)CC3=C([C@@H]2C4=CC=CC(Br)=C4)NC5=CC=CC=C53)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Aya Fathy, et al. Development of potent and selective tetrahydro-β-carboline-based HDAC6 inhibitors with promising activity against triple-negative breast cancer. RSC Med Chem. 2025 Apr 17. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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HDAC6-IN-57

All HDAC Isoforms