2,2,5,7,8-Pentamethyl-6-Chromanol
Based on 1 publication(s) in Google Scholar
2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines.
For research use only. We do not sell to patients.
- Purity: 99.30%
- CAS No.: 950-99-2
- Formula: C14H20O2
- Molecular Weight:220.31
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 2,2,5,7,8-Pentamethyl-6-Chromanol
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hepatocyte | IC50 |
0.17 μM
Compound: 27
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Tested for inhibition of ferrous salt/ascorbate induced lipidic peroxidation of membrane lipid of rat hepatocytes
Tested for inhibition of ferrous salt/ascorbate induced lipidic peroxidation of membrane lipid of rat hepatocytes
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[PMID: 15546710] |
2,2,5,7,8-Pentamethyl-6-Chromanol (4-12 μM, 90 min) inhibits the respiratory burst and migration of neutrophils induced by fMLP (HY-P0224), PMA (HY-18739) or LTB4 (HY-107608)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human neutrophils
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Concentration:4-12 μM
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Incubation Time:90 min
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Result:Inhibited the cell migration.
2,2,5,7,8-Pentamethyl-6-Chromanol (5-20 μg/g, iv, single dose) exhibits antiplatelet and antithrombotic activity in mouse Fluorescein sodium (HY-D0208)-induced microvascular thrombosis model and ADP (HY-W010918)-induced acute pulmonary thrombosis model[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CCl4 (HY-Y0298)-induced hepatotoxicity in mouse models[2]
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Dosage:1-10 mg/kg
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Administration:po, four times weekly for 8 weeks
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Result:Reduced levels of GPT and GOT in the serum.
Inhibited activities of GSH Px and GSH Rd in the liver tissue.
Decreased levels of glutathione and malondialdehyde in liver tissues.
Ameliorated hepatocellular necrosis, ballooning degeneration, and fatty degeneration in liver tissues.
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Animal Model:Fluorescein sodium (HY-D0208)-induced microvascular thrombosis model[3]
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Dosage:10-20 μg/g
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Administration:iv, single dose
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Result:Prolonged the time to induce platelet embolism and delayed the vascular occlusion time.
Chemical Information
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CAS No. 950-99-2
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Appearance Solid
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Molecular Weight 220.31
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Formula C14H20O2
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Color White to off-white
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SMILES
OC1=C(C)C(C)=C2C(CCC(C)(C)O2)=C1C
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Synonyms
PMC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Nature
2026 Jul;655(8121):240-250. PMID: 42236947
Solvent & Solubility
DMSO : ≥ 100 mg/mL (453.90 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (9.44 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (9.44 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Kyriakopoulos CE, et al. A multicenter phase 1/2a dose-escalation study of the antioxidant moiety of vitamin E 2,2,5,7,8-pentamethyl-6-chromanol (APC-100) in men with advanced prostate cancer. Invest New Drugs. 2016 Apr;34(2):225-30. [Content Brief]
[2]. Hsiao G, et al., The protective effects of PMC against chronic carbon tetrachloride-induced hepatotoxicity in vivo. Biol Pharm Bull. 2001 Nov;24(11):1271-6. [Content Brief]
[3]. Hsiao G, et al., Antithrombotic effect of PMC, a potent alpha-tocopherol analogue on platelet plug formation in vivo. Br J Haematol. 2002 Jun;117(3):699-704. [Content Brief]
[4]. Hsiao G, et al., Neuroprotective effects of PMC, a potent alpha-tocopherol derivative, in brain ischemia-reperfusion: reduced neutrophil activation and anti-oxidant actions. Biochem Pharmacol. 2007 Mar 1;73(5):682-93. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.5390 mL | 22.6951 mL | 45.3902 mL | 113.4754 mL |
| 5 mM | 0.9078 mL | 4.5390 mL | 9.0780 mL | 22.6951 mL | |
| 10 mM | 0.4539 mL | 2.2695 mL | 4.5390 mL | 11.3475 mL | |
| 15 mM | 0.3026 mL | 1.5130 mL | 3.0260 mL | 7.5650 mL | |
| 20 mM | 0.2270 mL | 1.1348 mL | 2.2695 mL | 5.6738 mL | |
| 25 mM | 0.1816 mL | 0.9078 mL | 1.8156 mL | 4.5390 mL | |
| 30 mM | 0.1513 mL | 0.7565 mL | 1.5130 mL | 3.7825 mL | |
| 40 mM | 0.1135 mL | 0.5674 mL | 1.1348 mL | 2.8369 mL | |
| 50 mM | 0.0908 mL | 0.4539 mL | 0.9078 mL | 2.2695 mL | |
| 60 mM | 0.0757 mL | 0.3783 mL | 0.7565 mL | 1.8913 mL | |
| 80 mM | 0.0567 mL | 0.2837 mL | 0.5674 mL | 1.4184 mL | |
| 100 mM | 0.0454 mL | 0.2270 mL | 0.4539 mL | 1.1348 mL |
2,2,5,7,8-Pentamethyl-6-Chromanol Related Classifications
HY-111024 Related Classifications
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