2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. GTx-007

GTx-007  (Synonyms: S-4)

Cat. No.: HY-12023 Purity: 99.67%
COA Handling Instructions

GTx-007 (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. GTx-007 (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity.

For research use only. We do not sell to patients.

GTx-007 Chemical Structure

GTx-007 Chemical Structure

CAS No. : 401900-40-1

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Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 61 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 77 In-stock
Estimated Time of Arrival: December 31
50 mg USD 154 In-stock
Estimated Time of Arrival: December 31
100 mg USD 209 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

GTx-007 (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. GTx-007 (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity[1][2].

In Vivo

GTx-007 (S-4) is only a partial agonist in the prostate and seminal vesicles, restoring them to 33.8 and 28.2% of intact animals, respectively[2].
GTx-007 significantly increased uterine expression of Wnt4 and Wnt7a[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6J mice[2].
Dosage: 0.5 mg/mouse.
Administration: Seven daily subcutaneous injections.
Result: Resulted in a highly heterogeneous pattern of AR expression in all compartments, with a significant increase of AR-positive cells in the luminal epithelium compared to VC.
Had approximately ten glands per uterine cross-section within an endometrium, with a compact stroma, consistent with overall endogenous steroid depletion.
Did not detect any impact of GTx-007 on body weight.
Molecular Weight

441.36

Appearance

Solid

Formula

C19H18F3N3O6
CAS No.
SMILES

O=C([[email protected]@](O)(COC1=CC=C(C=C1)NC(C)=O)C)NC2=CC=C(C(C(F)(F)F)=C2)[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (226.57 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2657 mL 11.3286 mL 22.6572 mL
5 mM 0.4531 mL 2.2657 mL 4.5314 mL
10 mM 0.2266 mL 1.1329 mL 2.2657 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.67%

COA (246 KB) LCMS (265 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

GTx-007401900-40-1S-4GTx007GTx 007S4S 4Androgen ReceptortissueselectiveprostatelowtoxicityInhibitorinhibitorinhibit

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