401900-40-1
401900-40-1
Chemical Structure
GTx-007
Synonym(s): S-4
- CAS No.: 401900-40-1
- Formula:C19H18F3N3O6
- Molecular Weight:441.36
IUPAC Name: (S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide
InChIKey: YVXVTLGIDOACBJ-SFHVURJKSA-N
SMILES: O=C([C@@](O)(COC1=CC=C(C=C1)NC(C)=O)C)NC2=CC=C(C(C(F)(F)F)=C2)[N+]([O-])=O
Biological Activity: GTx-007 (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. GTx-007 (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity[1][2].
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GTx-007 | 99.61% | GTx-007 (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. GTx-007 (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.66
HY-13273Ostarine -
Similarity Score 0.63
HY-W013272RHydroxyflutamide (Standard) -
Similarity Score 0.62
HY-112257S-23 -
Similarity Score 0.61
HY-19470Topilutamide -
Similarity Score 0.59
HY-W011958RN-(4-Nitro-3-(trifluoromethyl)phenyl)acetamide (Standard) -
Similarity Score 0.57
HY-171048GTx-027 -
Similarity Score 0.57
HY-B0022Flutamide -
Similarity Score 0.57
HY-135732SK33 -
Similarity Score 0.55
HY-W102330Bicalutamide sulfide -
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References
- [1]. Donghua Yin, et al. Pharmacodynamics of selective androgen receptor modulators. J Pharmacol Exp Ther. 2003 Mar;304(3):1334-40. [Content Brief]
- [2]. Ioannis Simitsidellis, et al. Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus. J Endocrinol. 2019 Sep;242(3):227-239. [Content Brief]
