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S-23 

Cat. No.: HY-112257 Purity: 99.95%
Handling Instructions

S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.

For research use only. We do not sell to patients.

S-23 Chemical Structure

S-23 Chemical Structure

CAS No. : 1010396-29-8

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Based on 1 publication(s) in Google Scholar

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Description

S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats[1][2].

IC50 & Target

Ki: 1.7 nM (Androgen receptor)[1]

In Vitro

S-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

By administration of S-23 to castrated animals, androgen-dependent organ weights increased in a dose-dependent manner. The ED50 of S-23 in the prostate and levator ani muscle is 0.43 and 0.079 mg/d, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats (in castrated male rats)[1]
Dosage: 0.01-3 mg
Administration: S.c.; daily for 14 d
Result: Androgen-dependent organ weights increased in a dose-dependent manner. At a dose rate as low as 0.1 mg/d, S-23 is able to selectively maintain the weight of the levator ani muscle at the intact control level, whereas its effects on the prostate and seminal vesicles are lower than 30% of those observed in intact controls.
Molecular Weight

416.75

Formula

C₁₈H₁₃ClF₄N₂O₃

CAS No.

1010396-29-8

SMILES

O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)[[email protected]@](C)(O)COC2=CC=C(Cl)C(F)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (239.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3995 mL 11.9976 mL 23.9952 mL
5 mM 0.4799 mL 2.3995 mL 4.7990 mL
10 mM 0.2400 mL 1.1998 mL 2.3995 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

S-23S23S 23Androgen ReceptortranscriptionalactivationCV-1cellscastratedprostateseminalvesiclelevatoranimuscleInhibitorinhibitorinhibit

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Product Name:
S-23
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HY-112257
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