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  3. SK33

SK33 

Cat. No.: HY-135732
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SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity.

For research use only. We do not sell to patients.

SK33 Chemical Structure

SK33 Chemical Structure

CAS No. : 1928724-23-5

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Description

SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1].

In Vitro

In LNCaPAR+ cells, SK33, demonstrates a significantly potent activity with IC50=0.2 μM. SK33 decreases cells entering S-phase in LNCaP cells. Treatment of LNCaP/BicR cells with increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth, with IC50 of approximately 5 μM for SK33[1].

Cell Viability Assay[1]

Cell Line: LNCaP/BicR cells
Concentration: 0.1-100 μM
Incubation Time: 96 hours
Result: Results in a dose-dependent response and an inhibition of cell growth.
In Vivo

SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity[1].

Animal Model: ARE-Luc mice[1]
Dosage: 50 mg/kg
Administration: Subcutaneously; 24 hours
Result: Inhibited AR transcriptional activity.
Molecular Weight

500.31

Formula

C₂₀H₁₃F₉N₂O₃

CAS No.

1928724-23-5

SMILES

O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)C(C)(O)COC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SK33SK 33SK-33Androgen ReceptorPC3cellsandrogenprostatecancerLNCaPtissueanaloguesInhibitorinhibitorinhibit

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