Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants

  • Bioorg Med Chem Lett. 2004 Dec 20;14(24):5971-4. doi: 10.1016/j.bmcl.2004.10.006.
Clara Cena  1 ,  Donatella Boschi ,  Gian Cesare Tron ,  Kostantin Chegaev ,  Loretta Lazzarato ,  Antonella Di Stilo ,  Manuela Aragno ,  Roberta Fruttero ,  Alberto Gasco
Affiliations
  • 1. Dipartimento di Scienza e Tecnologia del Farmaco, Via P. Giuria 9, I-10125 Torino, Italy.
PMID: 15546710 DOI: 10.1016/j.bmcl.2004.10.006
Abstract

A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate Phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.