Fluorescein sodium
Based on 14 publication(s) in Google Scholar
Fluorescein (Uranine) sodium is widely used as a fluorescent tracer in medicinal and biological applications and tumor infected tissues tracer. Fluorescein (Uranine) sodium is a representative green fluorophore that has been widely used as a scaffold of practically useful green fluorescent probes.
For research use only. We do not sell to patients.
- Purity: 95.36%
- CAS No.: 518-47-8
- Formula: C20H10Na2O5
- Molecular Weight:376.27
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Fluorescein sodium
More- Sci Bull. 2024 Mar 15;69(5):621-635. [Abstract]
- Food Chem. 2026 Mar 28:515:149066. [Abstract]
- Cell Death Dis. 2023 Feb 7;14(2):91. [Abstract]
- Food Sci Hum Wellness. 2026.
- J Agric Food Chem. 2025 Jul 16;73(28):17696-17712. [Abstract]
- Commun Biol. 2025 Apr 26;8(1):667. [Abstract]
- J Biol Chem. 2026 May 27:113207. [Abstract]
- Brain Res Bull. 2025 Sep:229:111479. [Abstract]
- J Neurosurg. 2018 Sep 7;131(3):724-734. [Abstract]
- Brain Res. 2024 Jul 15:1835:148919. [Abstract]
- Gene. 2025 Jan 27:149292. [Abstract]
- Dev Dyn. 2025 Jun;254(6):513-537. [Abstract]
- J Otol. 2025 Nov 13;20(4):211-218. [Abstract]
- Med Mol Morphol. 2025 Nov 10. [Abstract]
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 518-47-8
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Appearance Solid
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Molecular Weight 376.27
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Formula C20H10Na2O5
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Color Brown to reddish brown
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SMILES
O=C1OC2(C3=C(OC4=C2C=CC(O[Na])=C4)C=C(O[Na])C=C3)C5=C1C=CC=C5
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Synonyms
Uranine sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Publications (14)
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Journal Impact Factor
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Most Recent
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Sci Bull
Neurological impairment is crucial for tire rubber-derived contaminant 6PPDQ-induced acute toxicity to rainbow trout. [Abstract]2024 Mar 15;69(5):621-635. PMID: 38185590 -
Food Chem
Optimization of multi-enzyme coupled debittering process: Effect on bitterness and bioactive components of Shatianyu (Citrus grandis L. Osbeck) whole fruit powder. [Abstract]2026 Mar 28:515:149066. PMID: 41990492 -
Cell Death Dis
RBM3 suppresses stemness remodeling of prostate cancer in bone microenvironment by modulating N6-methyladenosine on CTNNB1 mRNA. [Abstract]2023 Feb 7;14(2):91. PMID: 36750551 -
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J Agric Food Chem
Tryptophan-Rich Diet Improves High-Fat Diet-Induced Cognitive Dysfunction and Blood-Brain Barrier Disruption in C57BL/6 Mice through FFAR3 Activation. [Abstract]2025 Jul 16;73(28):17696-17712. PMID: 40600293 -
Commun Biol
Nanocrystalline cellulose-geniposide complex enhances gut-brain axis modulation for depression treatment. [Abstract]2025 Apr 26;8(1):667. PMID: 40287572 -
J Biol Chem
Lactate-fueled H3K18 lactylation sustains ΔNp63α-dependent self-renewal in limbal epithelial stem cells. [Abstract]2026 May 27:113207. PMID: 42208899 -
Brain Res Bull
Sevoflurane reduces brain edema and improves blood-brain barrier by downregulating CaMKII to inhibit TMEM16A after cerebral ischemia injury both in vivo and in vitro. [Abstract]2025 Sep:229:111479. PMID: 40714175 -
J Neurosurg
Elucidating the kinetics of sodium fluorescein for fluorescence-guided surgery of glioma. [Abstract]2018 Sep 7;131(3):724-734. PMID: 30192200 -
Brain Res
2024 Jul 15:1835:148919. PMID: 38588846 -
Gene
Developmental endothelial locus-1 as a potential biomarker for the formation and progression of intracranial aneurysm. [Abstract]2025 Jan 27:149292. PMID: 39880340 -
Dev Dyn
Spatiotemporal characteristics of eustachian tube development in C57BL/6 mice: Correlation between morphological and functional maturation. [Abstract]2025 Jun;254(6):513-537. PMID: 39422348 -
J Otol
2025 Nov 13;20(4):211-218. PMID: 41311539 -
Med Mol Morphol
THBS1 inhibition alleviates inflammatory response by inhibiting TGF-β and NLRP3 inflammasome in experimental murine dry eye. [Abstract]2025 Nov 10. PMID: 41212269
Solvent & Solubility
H2O : 25 mg/mL (66.44 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Hirabayashi K, et al. Analysis of chemical equilibrium of silicon-substituted fluorescein and its application to develop a scaffold for red fluorescent probes. Anal Chem. 2015;87(17):9061-9069. [Content Brief]
[2]. Negm NA, et al. Fluorescein dye derivatives and their nanohybrids: Synthesis, characterization and antimicrobial activity. J Photochem Photobiol B. 2016;162:421-433. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.6577 mL | 13.2883 mL | 26.5767 mL | 66.4417 mL |
| 5 mM | 0.5315 mL | 2.6577 mL | 5.3153 mL | 13.2883 mL | |
| 10 mM | 0.2658 mL | 1.3288 mL | 2.6577 mL | 6.6442 mL | |
| 15 mM | 0.1772 mL | 0.8859 mL | 1.7718 mL | 4.4294 mL | |
| 20 mM | 0.1329 mL | 0.6644 mL | 1.3288 mL | 3.3221 mL | |
| 25 mM | 0.1063 mL | 0.5315 mL | 1.0631 mL | 2.6577 mL | |
| 30 mM | 0.0886 mL | 0.4429 mL | 0.8859 mL | 2.2147 mL | |
| 40 mM | 0.0664 mL | 0.3322 mL | 0.6644 mL | 1.6610 mL | |
| 50 mM | 0.0532 mL | 0.2658 mL | 0.5315 mL | 1.3288 mL | |
| 60 mM | 0.0443 mL | 0.2215 mL | 0.4429 mL | 1.1074 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Fluorescein sodium Related Classifications
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