c-Met/HDAC-IN-2
c-Met/HDAC-IN-2 is a highly potent c-Met and HDAC dual inhibitor with IC50s of 18.49 nM and 5.40 nM for HDAC1 and c-Met, respectively. c-Met/HDAC-IN-2 has antiproliferative activities against certain cancer cell lines. c-Met/HDAC-IN-2 can cause G2/M-phase arrest and induce apoptosis in HCT-116. c-Met/HDAC-IN-2 can be used for researching anti-cancer resistance.
For research use only. We do not sell to patients.
- CAS No.: 2740495-53-6
- Formula: C34H33N5O7
- Molecular Weight:623.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC1 18.49 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.22 μM
Compound: 14x
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Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
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[PMID: 32738414] |
| A549 | IC50 |
0.22 μM
Compound: 10
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 38733884] |
| HCT-116 | IC50 |
0.22 μM
Compound: 14x
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
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[PMID: 32738414] |
| MCF7 | IC50 |
1.59 μM
Compound: 14x
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
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[PMID: 32738414] |
| MCF7 | IC50 |
1.59 μM
Compound: 10
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 38733884] |
c-Met/HDAC-IN-2 (compound 14X) (0-20 μM; 72 hours) exhibits antiproliferative activities against HCT-116, MCF-7 and A549[1].
c-Met/HDAC-IN-2 (0.2-5 μM; 48 hours) induces of cancer cell apoptosis in a dose-dependent manner[1].
c-Met/HDAC-IN-2 (0.2-5 μM; 48 hours) significantly causes G2/M-phase arrest in HCT-116 cells in a dose dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116, MCF-7 and A549[1]
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Concentration:0-20 μM
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Incubation Time:72 hours
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Result:Exhibited antiproliferative activities against HCT-116, MCF-7 and A549 with IC50s of 0.22 ± 0.09 μM, 1.59 ± 0.06 μM and 0.22 ± 0.04 μM, respectively.
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Cell Line:HTC-116[1]
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Concentration:0.2, 1 and 5 μM
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Incubation Time:48 hours
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Result:The percentage of apoptotic cells was 4.19%, 11.53% and 21.48% at 0.2 μM, 1.0 μM and 5.0 μM, respectively.
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Cell Line:HTC-116[1]
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Concentration:0.2, 1 and 5 μM
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Incubation Time:48 hours
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Result:Significantly caused G2/M-phase arrest in HCT-116 cells in a dose dependent manner.
Chemical Information
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CAS No. 2740495-53-6
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Molecular Weight 623.66
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Formula C34H33N5O7
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SMILES
O=C(C1=NN(C2=CC=CC=C2)C=CC1=O)NC3=CC=C(OC4=CC=NC5=CC(OCCCCCCC(NO)=O)=C(OC)C=C45)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
c-Met/HDAC-IN-2 Related Classifications
HY-143462 Related Classifications
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