1. Cell Cycle/DNA Damage Epigenetics Protein Tyrosine Kinase/RTK Apoptosis
  2. HDAC c-Met/HGFR Apoptosis
  3. c-Met/HDAC-IN-2

c-Met/HDAC-IN-2 is a highly potent c-Met and HDAC dual inhibitor with IC50s of 18.49 nM and 5.40 nM for HDAC1 and c-Met, respectively. c-Met/HDAC-IN-2 has antiproliferative activities against certain cancer cell lines. c-Met/HDAC-IN-2 can cause G2/M-phase arrest and induce apoptosis in HCT-116. c-Met/HDAC-IN-2 can be used for researching anti-cancer resistance.

For research use only. We do not sell to patients.

c-Met/HDAC-IN-2 Chemical Structure

c-Met/HDAC-IN-2 Chemical Structure

CAS No. : 2740495-53-6

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Description

c-Met/HDAC-IN-2 is a highly potent c-Met and HDAC dual inhibitor with IC50s of 18.49 nM and 5.40 nM for HDAC1 and c-Met, respectively. c-Met/HDAC-IN-2 has antiproliferative activities against certain cancer cell lines. c-Met/HDAC-IN-2 can cause G2/M-phase arrest and induce apoptosis in HCT-116. c-Met/HDAC-IN-2 can be used for researching anti-cancer resistance[1].

IC50 & Target[1]

HDAC1

18.49 nM (IC50)

In Vitro

c-Met/HDAC-IN-2 (compound 14X) (0-20 μM; 72 hours) exhibits antiproliferative activities against HCT-116, MCF-7 and A549[1].
c-Met/HDAC-IN-2 (0.2-5 μM; 48 hours) induces of cancer cell apoptosis in a dose-dependent manner[1].
c-Met/HDAC-IN-2 (0.2-5 μM; 48 hours) significantly causes G2/M-phase arrest in HCT-116 cells in a dose dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: HCT-116, MCF-7 and A549[1]
Concentration: 0-20 μM
Incubation Time: 72 hours
Result: Exhibited antiproliferative activities against HCT-116, MCF-7 and A549 with IC50s of 0.22 ± 0.09 μM, 1.59 ± 0.06 μM and 0.22 ± 0.04 μM, respectively.

Apoptosis Analysis

Cell Line: HTC-116[1]
Concentration: 0.2, 1 and 5 μM
Incubation Time: 48 hours
Result: The percentage of apoptotic cells was 4.19%, 11.53% and 21.48% at 0.2 μM, 1.0 μM and 5.0 μM, respectively.

Cell Cycle Analysis

Cell Line: HTC-116[1]
Concentration: 0.2, 1 and 5 μM
Incubation Time: 48 hours
Result: Significantly caused G2/M-phase arrest in HCT-116 cells in a dose dependent manner.
Molecular Weight

623.66

Formula

C34H33N5O7

CAS No.
SMILES

O=C(C1=NN(C2=CC=CC=C2)C=CC1=O)NC3=CC=C(OC4=CC=NC5=CC(OCCCCCCC(NO)=O)=C(OC)C=C45)C=C3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
c-Met/HDAC-IN-2
Cat. No.:
HY-143462
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