2740495-53-6
Chemical Structure
c-Met/HDAC-IN-2
- CAS No.: 2740495-53-6
- Formula:C34H33N5O7
- Molecular Weight:623.66
IUPAC Name: N-(4-((7-((7-(hydroxyamino)-7-oxoheptyl)oxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-4-oxo-1-phenyl-1,4-dihydropyridazine-3-carboxamide
InChIKey: GHRAGOBMSUDFEQ-UHFFFAOYSA-N
SMILES: O=C(C1=NN(C2=CC=CC=C2)C=CC1=O)NC3=CC=C(OC4=CC=NC5=CC(OCCCCCCC(NO)=O)=C(OC)C=C45)C=C3
Biological Activity: c-Met/HDAC-IN-2 is a highly potent c-Met and HDAC dual inhibitor with IC50s of 18.49 nM and 5.40 nM for HDAC1 and c-Met, respectively. c-Met/HDAC-IN-2 has antiproliferative activities against certain cancer cell lines. c-Met/HDAC-IN-2 can cause G2/M-phase arrest and induce apoptosis in HCT-116. c-Met/HDAC-IN-2 can be used for researching anti-cancer resistance[1].
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c-Met/HDAC-IN-2 | c-Met/HDAC-IN-2 is a highly potent c-Met and HDAC dual inhibitor with IC50s of 18.49 nM and 5.40 nM for HDAC1 and c-Met, respectively. c-Met/HDAC-IN-2 has antiproliferative activities against certain cancer cell lines. c-Met/HDAC-IN-2 can cause G2/M-phase arrest and induce apoptosis in HCT-116. c-Met/HDAC-IN-2 can be used for researching anti-cancer resistance. | |||||||||||||||||||||
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