HDAC-IN-93
HDAC-IN-93 is a HDAC inhibitor with promising total pan-HDAC inhibitory activity. HDAC-IN-93 demonstrates significant broad-spectrum antiproliferative activity across various cancer cell lines. HDAC-IN-93 induces cell apoptosis along with necrosis. HDAC-IN-93 can be used for the studies of prostate cancer and breast cancer.
For research use only. We do not sell to patients.
- Formula: C18H14N2O3
- Molecular Weight:306.32
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Caspase Isoforms
More
Biological Activity
|
HDAC6 |
HDAC7 |
HDAC8 |
Bax |
Caspase 3 |
Bcl-2 |
HDAC-IN-93 (Compound 17) is sensitive to a variety of cancer cell lines, with particularly significant effects on prostate cancer PC-3 cells and breast cancer MCF-7 cells with IC50 values of 4.1 μM and 20.8 μM, respectively[1].
HDAC-IN-93 (4.1 μM, 24 h) causes a significant increase in the number of cells in the SubG0-G1 phase, and induces early apoptosis in MCF-7 cells[1].
HDAC-IN-93 (4.1 μM, 24 h) upregulates pro-apoptotic genes (Bax, Cyt-C, Caspase-3) and downregulates anti-apoptotic genes (Bcl-2) in MCF-7 cells[1].
HDAC-IN-93 (4.1 μM, 24 h) shows total HDAC inhibitory activity of 66.1 % at MCF-7 although shows relatively weak direct inhibitory activity against specific HDAC subtypes (6, 7, 8)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MCF-7 cells
-
Concentration:4.1 μM
-
Incubation Time:24 h
-
Result:Significant increased the subG0-G1 phase cell population (21.5%).
-
Cell Line:MCF-7 cells
-
Concentration:4.1 μM
-
Incubation Time:24 h
-
Result:Induced early apoptosis.
-
Cell Line:MCF-7 cells
-
Concentration:4.1 μM
-
Incubation Time:24 h
-
Result:Upregulated Bax, Cyt-C and Caspase-3 and downregulated the Bcl-2.
Chemical Information
-
Molecular Weight 306.32
-
Formula C18H14N2O3
-
SMILES
N/C(C(C=C1)=CC=C1/C=C/C2=CC(C3=CC=CC=C3O2)=O)=N\O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz