ML234
ML234 is a dual inhibitor against EZH2/LSD1 with IC50 values of 0.09 and 0.12 μM, respectively. ML234 displays an excellent antiproliferative capacity against prostate cancer cell lines LNCAP, PC3 and 22RV1. ML234 suppresses the tumor growth in the 22RV1 xenograft mouse model. ML234 is promising for research of anticancer agents in prostate cancer.
For research use only. We do not sell to patients.
- CAS No.: 3068378-07-1
- Formula: C43H58N4O6
- Molecular Weight:726.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Histone Methyltransferase Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CWR22R | GI50 |
3.96 μM
Compound: 9j; ML234
|
Growth inhibition of human 22Rv1 cells incubated for 6 to 7 days by MTS assay
Growth inhibition of human 22Rv1 cells incubated for 6 to 7 days by MTS assay
|
[PMID: 39196854] |
| LNCaP | GI50 |
1.63 μM
Compound: 9j; ML234
|
Growth inhibition of human LNCaP cells incubated for 6 to 7 days by MTS assay
Growth inhibition of human LNCaP cells incubated for 6 to 7 days by MTS assay
|
[PMID: 39196854] |
| PC-3 | GI50 |
1.04 μM
Compound: 9j; ML234
|
Growth inhibition of human PC-3 cells incubated for 6 to 7 days by MTS assay
Growth inhibition of human PC-3 cells incubated for 6 to 7 days by MTS assay
|
[PMID: 39196854] |
Chemical Information
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CAS No. 3068378-07-1
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Molecular Weight 726.94
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Formula C43H58N4O6
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SMILES
CC(C(C(NCC1=C(C=C(NC1=O)C)C)=O)=CC(C2=CC=C([C@@H]3C[C@H]3N(C(OC(C)(C)C)=O)CC4CCOCC4)C=C2)=C5)=C5N(CC)C6CCOCC6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)