Microtubule inhibitor 3
Compounds 17O (ic50= 14.0 nm, NCI-H460) and 17p (ic50= 2.9 nm, NCI-H460) and furan groups showed effective cytotoxic activity against various human cancer cell lines at the nanomolar level.
For research use only. We do not sell to patients.
- CAS No.: 1236141-96-0
- Formula: C26H23FN4O3
- Molecular Weight:458.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.8 nM
Compound: 16j
|
Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay
Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay
|
[PMID: 22727370] |
| BXPC-3 | IC50 |
0.6 nM
Compound: 1
|
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 32278711] |
| HeLa | IC50 |
1.7 nM
Compound: 16j
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Cytotoxicity against human HeLa cells after 48 hrs by WST-8 assay
Cytotoxicity against human HeLa cells after 48 hrs by WST-8 assay
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[PMID: 22727370] |
| HT-29 | IC50 |
0.5 nM
Compound: 16j
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Cytotoxicity against human HT-29 cells after 48 hrs by XTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by XTT assay
|
[PMID: 22727370] |
| HT-29 | IC50 |
0.6 nM
Compound: 1
|
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 32278711] |
| NCI-H460 | IC50 |
3.8 nM
Compound: 1
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Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 32278711] |
| NCI-H460 | IC50 |
3.8 nM
Compound: 6b
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Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by SRB assay
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by SRB assay
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[PMID: 31759826] |
Chemical Information
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CAS No. 1236141-96-0
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Molecular Weight 458.48
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Formula C26H23FN4O3
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SMILES
CC(C)(C1=C(N=CN1)/C=C2NC(/C(NC\2=O)=C/C3=CC(C(C4=CC=C(C=C4)F)=O)=CC=C3)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Microtubule inhibitor 3 Related Classifications
HY-147724 Related Classifications
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