EGFR-IN-51
EGFR-IN-51 (Compound 6) is a potent EGFR inhibitor with IC50 values of 0.493, 102.60 and 461.63 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-51 shows cytotoxic activity against cancer cell lines and induces apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 2418549-32-1
- Formula: C21H15N3O2S
- Molecular Weight:373.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
|
EGFR 0.493 μM (IC50) |
EGFRL858R 102.60 μM (IC50) |
EGFRT790M 461.63 μM (IC50) |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
1.71 μM
Compound: 6
|
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 32361329] |
| HepG2 | IC50 |
2.14 μM
Compound: 6
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 32361329] |
| MCF7 | IC50 |
4.63 μM
Compound: 6
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 32361329] |
| WI-38 | IC50 |
227 μM
Compound: 6
|
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 32361329] |
Chemical Information
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CAS No. 2418549-32-1
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Molecular Weight 373.43
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Formula C21H15N3O2S
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SMILES
S=C(NC1=C2C=CC=CC2=NC3=C1C=CC=C3)NC4=CC=C5OCOC5=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)