2418549-32-1
2418549-32-1
Chemical Structure
EGFR-IN-51
- CAS No.: 2418549-32-1
- Formula:C21H15N3O2S
- Molecular Weight:373.43
IUPAC Name: 1-(acridin-9-yl)-3-(benzo[d][1,3]dioxol-5-yl)thiourea
InChIKey: UXZDJRJJDCBSLW-UHFFFAOYSA-N
SMILES: S=C(NC1=C2C=CC=CC2=NC3=C1C=CC=C3)NC4=CC=C5OCOC5=C4
Biological Activity: EGFR-IN-51 (Compound 6) is a potent EGFR inhibitor with IC50 values of 0.493, 102.60 and 461.63 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-51 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].
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EGFR-IN-51 | EGFR-IN-51 (Compound 6) is a potent EGFR inhibitor with IC50 values of 0.493, 102.60 and 461.63 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-51 shows cytotoxic activity against cancer cell lines and induces apoptosis. | |||||||||||||||||||||
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References
Keywords
