hGAPDH-IN-1
hGAPDH-IN-1, a 3-bromo-4,5-dihydroisoxazole derivative, is a specific and potent hGAPDH covalent inhibitor. hGAPDH-IN-1 reduces cancer cell growth in different pancreatic cancer cell lines.
For research use only. We do not sell to patients.
- CAS No.: 3044004-63-6
- Formula: C12H12BrNO
- Molecular Weight:266.13
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MIA PaCa-2 | IC50 |
15.2 μM
Compound: 11
|
Antiproliferative activity in human MIA PaCa-2 cells measured after 48 hrs by Crystal violet staining based analysis
Antiproliferative activity in human MIA PaCa-2 cells measured after 48 hrs by Crystal violet staining based analysis
|
[PMID: 37058971] |
| PANC-1 | IC50 |
21.72 μM
Compound: 11
|
Antiproliferative activity in human PANC-1 cells measured after 48 hrs by Crystal violet staining based analysis
Antiproliferative activity in human PANC-1 cells measured after 48 hrs by Crystal violet staining based analysis
|
[PMID: 37058971] |
hGAPDH-IN-1 (compound 11; 1-100 μM; 48 hours) turns out to strongly reduce cancer cell growth in all tested cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:PaCa-3, PaCa-44, PANC-1, and MIA PaCa-2 cell lines
-
Concentration:1, 2.5, 5, 10, 25, 50, 100 μM
-
Incubation Time:48 hours
-
Result:Turned out to strongly reduce cancer cell growth in all tested cell lines.
Had IC50s of 4.69 μM, 16.16 μM, 21.72 μM, 15.2 μM for PaCa-3, PaCa-44, PANC-1, and MIA PaCa-2 cell lines, respectively.
Chemical Information
-
CAS No. 3044004-63-6
-
Molecular Weight 266.13
-
Formula C12H12BrNO
-
SMILES
BrC1=NOC2(C1)CCCC3=C2C=CC=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hGAPDH-IN-1 Related Classifications
HY-149076 Related Classifications
Powered by Bioz