hGAPDH-IN-1
hGAPDH-IN-1, a 3-bromo-4,5-dihydroisoxazole derivative, is a specific and potent hGAPDH covalent inhibitor. hGAPDH-IN-1 reduces cancer cell growth in different pancreatic cancer cell lines.
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- CAS No.: 3044004-63-6
- Formule: C12H12BrNO
- Masse moléculaire:266.13
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MIA PaCa-2 | IC50 |
15.2 μM
Compound: 11
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Antiproliferative activity in human MIA PaCa-2 cells measured after 48 hrs by Crystal violet staining based analysis
Antiproliferative activity in human MIA PaCa-2 cells measured after 48 hrs by Crystal violet staining based analysis
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[PMID: 37058971] |
| PANC-1 | IC50 |
21.72 μM
Compound: 11
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Antiproliferative activity in human PANC-1 cells measured after 48 hrs by Crystal violet staining based analysis
Antiproliferative activity in human PANC-1 cells measured after 48 hrs by Crystal violet staining based analysis
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[PMID: 37058971] |
In Vitro
hGAPDH-IN-1 (compound 11; 1-100 μM; 48 hours) turns out to strongly reduce cancer cell growth in all tested cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PaCa-3, PaCa-44, PANC-1, and MIA PaCa-2 cell lines
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Concentration:1, 2.5, 5, 10, 25, 50, 100 μM
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Incubation Time:48 hours
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Result:Turned out to strongly reduce cancer cell growth in all tested cell lines.
Had IC50s of 4.69 μM, 16.16 μM, 21.72 μM, 15.2 μM for PaCa-3, PaCa-44, PANC-1, and MIA PaCa-2 cell lines, respectively.
Chemical Information
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CAS No. 3044004-63-6
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Masse moléculaire 266.13
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Formule C12H12BrNO
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SMILES
BrC1=NOC2(C1)CCCC3=C2C=CC=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hGAPDH-IN-1 Related Classifications
HY-149076 Related Classifications
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