1. Apoptosis
    Protein Tyrosine Kinase/RTK
  2. Apoptosis
    ROS
  3. Anticancer agent 59

Anticancer agent 59 

Cat. No.: HY-146462
Handling Instructions

Anticancer agent 59 (compound 11) has inhibitory activity against kinds of cancer cell lines, especially in A549 with IC50 of 0.2 μM. Anticancer agent 59 induces apoptosis and an increase of Ca2+ and ROS in cancer cells. Anticancer agent 59 significantly decreases mitochondrial membrane potential. Anticancer agent 59 can suppress tumor growth in A549 mouse xenograft model.

For research use only. We do not sell to patients.

Anticancer agent 59 Chemical Structure

Anticancer agent 59 Chemical Structure

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Description

Anticancer agent 59 (compound 11) has inhibitory activity against kinds of cancer cell lines, especially in A549 with IC50 of 0.2 μM. Anticancer agent 59 induces apoptosis and an increase of Ca2+ and ROS in cancer cells. Anticancer agent 59 significantly decreases mitochondrial membrane potential. Anticancer agent 59 can suppress tumor growth in A549 mouse xenograft model[1].

IC50 & Target

IC50: 0.2 μM in A549[1]

Molecular Weight

673.92

Formula

C42H59NO6

SMILES

O=C([[email protected]]1(CC[[email protected]@]2(CC[[email protected]@]3(C([[email protected]@]2(C1)[H])=CC(C4[[email protected]]5(CC[[email protected]@H](C(C)(C5CC[[email protected]]43C)C)OC(CC)=O)C)=O)C)C)C)N[[email protected]@](CC6=CC=CC=C6)(C(O)=O)[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Anticancer agent 59
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