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Cat. No.: HY-142772

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Y08284

Y08284 is a potent, selective, oral active CBP bromodomain inhibitor with an IC50 of 4.21 nM. Y08284 suppresses the proliferation of prostate cancer cell lines LNCaP, C4-2B, and 22Rv1. Antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 2688745-47-1
Formula: C₂₆H₂₅FN₄O₄
Molecular Weight:476.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Y08284 Chemical Structure

CAS No.: 2688745-47-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Histone Acetyltransferase Isoforms :

All Epigenetic Reader Domain Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CWR22R	IC₅₀	2.04 μM Compound: 9g; Y08284	Antiproliferative activity against human 22Rv1 cells assessed as cell growth inhibition by Celltiter-Glo assay Antiproliferative activity against human 22Rv1 cells assessed as cell growth inhibition by Celltiter-Glo assay	[PMID: 34962793]
LNCaP	IC₅₀	0.59 μM Compound: 9g; Y08284	Antiproliferative activity against human LNCaP cells assessed as cell growth inhibition by Celltiter-Glo assay Antiproliferative activity against human LNCaP cells assessed as cell growth inhibition by Celltiter-Glo assay	[PMID: 34962793]
LNCaP C4-2B	IC₅₀	6.43 μM Compound: 9g; Y08284	Antiproliferative activity against human LNCaP C4-2B cells assessed as inhibition of cell growth by Celltiter-Glo assay Antiproliferative activity against human LNCaP C4-2B cells assessed as inhibition of cell growth by Celltiter-Glo assay	[PMID: 34962793]

In Vivo

Y08284 demonstrates favorable cell permeability and good pharmacokinetic properties, with oral bioavailability of 25.9%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2688745-47-1
Molecular Weight 476.50
Formula C₂₆H₂₅FN₄O₄
SMILES

O=C(C1=C2C=C(OC)C=CN2C(C(C)=O)=C1)NC3=CC(C(O)C)=CC(C4=CN(C5CC5)N=C4)=C3F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiang Q, et al. Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer. J Med Chem. 2022;65(1):785-810. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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Y08284

All Histone Acetyltransferase Isoforms

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Y08284 Related Classifications

HY-142772 Related Classifications