Boc-Pip-alkyne-Ph-COOH
Boc-Pip-alkyne-Ph-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-Pip-alkyne-Ph-COOH can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 effectively induces degradation of androgen receptor (AR) protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM. Boc-Pip-alkyne-Ph-COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- CAS No.: 2581824-70-4
- Formula: C19H23NO4
- Molecular Weight:329.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
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Alkyl/ether |
Chemical Information
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CAS No. 2581824-70-4
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Molecular Weight 329.39
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Formula C19H23NO4
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SMILES
OC(C1=CC=C(C#CC2CCN(C(OC(C)(C)C)=O)CC2)C=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Boc-Pip-alkyne-Ph-COOH Related Classifications
HY-133044 Related Classifications
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