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  3. Boc-Pip-alkyne-Ph-COOH

Boc-Pip-alkyne-Ph-COOH 

Cat. No.: HY-133044
Handling Instructions

Boc-Pip-alkyne-Ph-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-Pip-alkyne-Ph-COOH can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 effectively induces degradation of androgen receptor (AR) protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM.

For research use only. We do not sell to patients.

Boc-Pip-alkyne-Ph-COOH Chemical Structure

Boc-Pip-alkyne-Ph-COOH Chemical Structure

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Description

Boc-Pip-alkyne-Ph-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-Pip-alkyne-Ph-COOH can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 effectively induces degradation of androgen receptor (AR) protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM[1].

IC50 & Target[1]

Alkyl/ether

 

Molecular Weight

329.39

Formula

C₁₉H₂₃NO₄

SMILES

OC(C1=CC=C(C#CC2CCN(C(OC(C)(C)C)=O)CC2)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Boc-Pip-alkyne-Ph-COOHPROTAC LinkerPROTAClinkeralkyletherandrogenreceptorARD-266Inhibitorinhibitorinhibit

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Product name:
Boc-Pip-alkyne-Ph-COOH
Cat. No.:
HY-133044
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