Antiproliferative agent-15
Based on 1 Customer Validation
Antiproliferative agent-15 is an thienopyrimidine derivated anticancer agent. Antiproliferative agent-15 shows antiproliferative activity against human colon (HCT116 and HCT15) and brain (LN-229 and GBM-10) cancer cell lines.
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- Purity: 99.18%
- CAS No.: 19819-18-2
- 화학식: C16H14N2OS
- 분자량:282.37
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
>100 μM
Compound: 6a
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Antiproliferative activity against human A2780 cells after 72 hrs by MTT assay
Antiproliferative activity against human A2780 cells after 72 hrs by MTT assay
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[PMID: 28759878] |
| CHO | IC50 |
>100 μM
Compound: 6a
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Cytotoxicity against CHO cells assessed as reduction in cell survival after 72 hrs by MTT assay
Cytotoxicity against CHO cells assessed as reduction in cell survival after 72 hrs by MTT assay
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[PMID: 28759878] |
| HCT-116 | IC50 |
>10 μM
Compound: 4e
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Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability measured after 24 to 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability measured after 24 to 48 hrs by MTT assay
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[PMID: 32153186] |
| HCT-116 | IC50 |
8.3 μM
Compound: 6a
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Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
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[PMID: 28759878] |
| HCT-15 | IC50 |
4.8 μM
Compound: 6a
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Antiproliferative activity against human HCT15 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT15 cells after 72 hrs by MTT assay
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[PMID: 28759878] |
| LN-229 | IC50 |
18.3 μM
Compound: 6a
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Antiproliferative activity against human LN229 cells after 72 hrs by MTT assay
Antiproliferative activity against human LN229 cells after 72 hrs by MTT assay
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[PMID: 28759878] |
| MCF7 | IC50 |
>30 μM
Compound: 6c
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Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
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[PMID: 29172540] |
| MDA-MB-231 | IC50 |
>30 μM
Compound: 6c
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Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
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[PMID: 29172540] |
Antiproliferative agent-15 (compound 6a) shows antiproliferative activity against human colon (HCT116 and HCT15), brain (LN-229 and GBM-10) cancer cell lines, with IC50 values of 8.3 μM, 4.8 μM, 18.3 μM, and 12 μM, respectively. However, Antiproliferative agent-15 has no active against ovarian (A2780) cancer cell lines and normal cell line (CHO)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 19819-18-2
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Appearance Solid
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분자량 282.37
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화학식 C16H14N2OS
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Color Off-white to light yellow
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SMILES
O=C1C(C(CCCC2)=C2S3)=C3N=C(C4=CC=CC=C4)N1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
DMSO : 1.67 mg/mL (5.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5415 mL | 17.7074 mL | 35.4148 mL | 88.5369 mL |
| 5 mM | 0.7083 mL | 3.5415 mL | 7.0830 mL | 17.7074 mL |
Antiproliferative agent-15 Related Classifications
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