ZW-18-116

Cat. No.: HY-180550: Data Sheet Handling Instructions
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ZW-18-116 (compound 9) is a dual-target PROTAC degrader for the oncoproteins TRKA and RET. ZW-18-116 induces the degradation of oncoproteins TRKA and RET by recruiting the CRBN E3 ligase. ZW-18-116 exhibits potent anti-proliferative activity in various cancer cell lines harboring RET or TRKA fusions. ZW-18-116 can be used for RET or TRKA-derived cancer research, such as thyroid, lung, and colon cancers.
(Pink: RET and VEGFR ligand (HY-U00437); Blue: Cereblon ligand (HY-10984); Black: linker).

For research use only. We do not sell to patients.

ZW-18-116 Chemical Structure

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MOQ		Minimum order quantity
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This product is a controlled substance and not for sale in your territory.

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TrkA TrkB TrkC Trk

Biological Activity
Purity & Documentation
References
Customer Review

Description

ZW-18-116 (compound 9) is a dual-target PROTAC degrader for the oncoproteins TRKA and RET. ZW-18-116 induces the degradation of oncoproteins TRKA and RET by recruiting the CRBN E3 ligase. ZW-18-116 exhibits potent anti-proliferative activity in various cancer cell lines harboring RET or TRKA fusions. ZW-18-116 can be used for RET or TRKA-derived cancer research, such as thyroid, lung, and colon cancers^[1]. (Pink: RET and VEGFR ligand (HY-U00437); Blue: Cereblon ligand (HY-10984); Black: linker).

IC₅₀ & Target^[1]

TrkA

Molecular Weight

884.93

Formula

C₄₆H₄₈N₁₀O₉

SMILES

O=C(NC1=NOC(C(C)(C)C)=C1)CC2=CC=C(N3C=NC4=CC(C5=CN(CC(NCCOCCOCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O)N=C5)=CC=C34)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Moccia M, et al. Discovery of a Proteolysis Targeting Chimera for TRKA and RET-derived oncoproteins. Sci Rep. 2025 Nov 25;15(1):41770. [Content Brief]

ZW-18-116 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZW-18-116PROTACsRETTrk ReceptorTropomyosin related kinase receptoroncoproteinsCRBN E3 ligaseRET or TRKA-derived cancerInhibitorinhibitorinhibit

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