2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. MLS-2064

MLS-2064 is a 3'-substituted 7-haloindirubin with antitumor activity. MLS-2064 induces caspase-independent cell death. MLS-2064 induces dose-dependent cell death in various human cancer cell lines. MLS-2064 shows no significant inhibitory activity against CDK1 and CDK5 kinases, and only weak inhibitory activity against GSK-3 kinase (IC50: 5 μM). MLS-2064 can be used in research related to colon cancer, breast cancer, lung cancer, prostate cancer, liver cancer, and neuroblastoma.

For research use only. We do not sell to patients.

MLS-2064

MLS-2064 Chemical Structure

CAS No. : 906660-74-0

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MLS-2064 Related Antibodies

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Description

MLS-2064 is a 3'-substituted 7-haloindirubin with antitumor activity. MLS-2064 induces caspase-independent cell death. MLS-2064 induces dose-dependent cell death in various human cancer cell lines. MLS-2064 shows no significant inhibitory activity against CDK1 and CDK5 kinases, and only weak inhibitory activity against GSK-3 kinase (IC50: 5 μM). MLS-2064 can be used in research related to colon cancer, breast cancer, lung cancer, prostate cancer, liver cancer, and neuroblastoma[1].

In Vitro

MLS-2064 (compound 13j) (8 h) potently reduces the viability of various human tumor cell lines and embryonic kidney cell lines[1].
MLS-2064 (48 h) induces caspase-independent cell death in SH-SY5Y cells, as its cell viability inhibitory activity is not affected by the caspase inhibitor Q-VD-OPh[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MLS-2064 Related Antibodies

Cell Viability Assay[1]

Cell Line: HT-29, HCT116 colon cancer, MDA-MB-231 breast cancer, A549 lung cancer, PC3 prostate cancer, 5L, BP8, F1, Huh7 hepatoma, HEK293 embryonic kidney cells
Concentration: /
Incubation Time: 48 h
Result: Exhibited the following IC50 values for cell viability inhibition after 48 h: HT-29 (6.3 μM), HCT116 (5.4 μM), MDA-MB-231 (5.3 μM), A549 (5.9 μM), PC3 (6.1 μM), 5L (5.2 μM), BP8 (5.6 μM), F1 (1.7 μM), Huh7 (5.3 μM), HEK293 (5.0 μM).
Molecular Weight

541.27

Formula

C22H24BrCl2N5O2
CAS No.
SMILES

O=C(/C(C1=CC=C2)=C(NC3=CC=CC=C34)/C4=N/OCCN5CCNCC5)NC1=C2Br.Cl.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MLS-2064 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MLS-2064906660-74-0MLS2064MLS 2064GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3lung cancerprostate cancerCDK5breast cancerhuman cancer cell linescaspase-independent cell deathSH-SY5Y cellsCDK1colon cancerInhibitorinhibitorinhibit

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