906660-74-0
Chemical Structure
MLS-2064
- CAS No.: 906660-74-0
- Formula:C22H24BrCl2N5O2
- Molecular Weight:541.27
IUPAC Name: (2Z,3E)-7'-bromo-3-((2-(piperazin-1-yl)ethoxy)imino)-[2,3'-biindolinylidene]-2'-one hydrochloride
InChIKey: JXVVUJJCDZDPLO-CRNVARIRSA-N
SMILES: O=C(/C(C1=CC=C2)=C(NC3=CC=CC=C34)/C4=N/OCCN5CCNCC5)NC1=C2Br.Cl.Cl
Biological Activity: MLS-2064 is a 3'-substituted 7-haloindirubin with antitumor activity. MLS-2064 induces caspase-independent cell death. MLS-2064 induces dose-dependent cell death in various human cancer cell lines. MLS-2064 shows no significant inhibitory activity against CDK1 and CDK5 kinases, and only weak inhibitory activity against GSK-3 kinase (IC50: 5 μM). MLS-2064 can be used in research related to colon cancer, breast cancer, lung cancer, prostate cancer, liver cancer, and neuroblastoma[1].
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MLS-2064 | MLS-2064 is a 3'-substituted 7-haloindirubin with antitumor activity. MLS-2064 induces caspase-independent cell death. MLS-2064 induces dose-dependent cell death in various human cancer cell lines. MLS-2064 shows no significant inhibitory activity against CDK1 and CDK5 kinases, and only weak inhibitory activity against GSK-3 kinase (IC50: 5 μM). MLS-2064 can be used in research related to colon cancer, breast cancer, lung cancer, prostate cancer, liver cancer, and neuroblastoma. | |||||||||||||||||||||
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Keywords
