(19R)-13-Deoxy-19-hydroxyenmein
(19R)-13-Deoxy-19-hydroxyenmein is the parent compound of enmein-type diterpenoid analogs. (19R)-13-Deoxy-19-hydroxyenmein has anti-proliferative activities with IC50 values of 0.41, 0.85, 0.43, 1.89 μM against human cancer cell lines K562, MGC-803, CaEs-17, and Bel-7402, respectively.
For research use only. We do not sell to patients.
- CAS No.: 16763-48-7
- Formula: C20H26O6
- Molecular Weight:362.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
50.86 μM
Compound: 2
|
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
|
[PMID: 22483090] |
| Bel-7402 | IC50 |
32.09 μM
Compound: 2
|
Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay
Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay
|
[PMID: 29407983] |
| Bel-7402 | IC50 |
32.96 μM
Compound: 10
|
Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay
Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay
|
[PMID: 23644204] |
| Bel-7402 | IC50 |
32.96 μM
Compound: 2
|
Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay
Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay
|
[PMID: 22483090] |
| Bel7402/5-FU | IC50 |
44.27 μM
Compound: 2
|
Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by MTT assay
Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by MTT assay
|
[PMID: 29407983] |
| HeLa | IC50 |
60.7 μM
Compound: 2
|
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
|
[PMID: 22483090] |
| HL-60 | IC50 |
28.07 μM
Compound: 2
|
Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
|
[PMID: 29407983] |
| K562 | IC50 |
8.11 μM
Compound: 10
|
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
|
[PMID: 23644204] |
| K562 | IC50 |
8.11 μM
Compound: 2
|
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
|
[PMID: 22483090] |
| L02 | IC50 |
27.06 μM
Compound: 2
|
Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay
Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay
|
[PMID: 29407983] |
| MCF7 | IC50 |
68.2 μM
Compound: 2
|
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
|
[PMID: 22483090] |
| MGC-803 | IC50 |
14.21 μM
Compound: 10
|
Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay
Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay
|
[PMID: 23644204] |
| PC-3 | IC50 |
30.55 μM
Compound: 2
|
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
|
[PMID: 29407983] |
Chemical Information
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CAS No. 16763-48-7
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Molecular Weight 362.42
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Formula C20H26O6
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SMILES
O[C@H]1[C@@](C2(C)C)([H])[C@]([C@@](CC2)([H])OC3=O)(CO1)[C@@](CC[C@@]4([H])C5=C)([H])[C@]3(C5=O)C4O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)