TM5441 sodium
Based on 10 publication(s) in Google Scholar
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM. TM5441 induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence.
For research use only. We do not sell to patients.
- CAS No.: 2319722-53-5
- Formula: C21H16ClN2NaO6
- Molecular Weight:450.80
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) TM5441 sodium
More- Kidney Int. 2023 Sep;104(3):508-525. [Abstract]
- Sci Adv. 2025 Jun 6;11(23):eadu2695. [Abstract]
- Eur J Pharmacol. 2024 Jul 26:176843. [Abstract]
- Eur J Pharm Sci. 2020 Feb 15;143:105195. [Abstract]
- Sci Rep. 2023 Sep 27;13(1):16210. [Abstract]
- Biol Pharm Bull. 2023 Oct 10;46(12):1753-1760. [Abstract]
- bioRxiv. 2025 May 12.
- bioRxiv. 2024 October 03.
- bioRxiv. 2023 Nov 26.
- Res Sq. 2023 Jun 5:rs.3.rs-2986934. [Abstract]
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Bio/Physico-chemical Assay
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RT-PCR
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RT-PCR
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WB
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Biological Activity
Chemical Information
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CAS No. 2319722-53-5
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Molecular Weight 450.80
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Formula C21H16ClN2NaO6
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SMILES
ClC1=CC=C(NC(COCC(NC2=CC=CC(C3=COC=C3)=C2)=O)=O)C(C(O[Na])=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (10)
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Journal Impact Factor
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Most Recent
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Kidney Int
Dual deletion of guanylyl cyclase-A and p38 mitogen-activated protein kinase in podocytes with aldosterone administration causes glomerular intra-capillary thrombi. [Abstract]2023 Sep;104(3):508-525. PMID: 37356621
TM5441 sodium purchased from MedChemExpress. Usage Cited in: Kidney Int. 2023 Sep;104(3):508-525. [Abstract]
TM5441 decreased SERPINE1, TGFB1 and CDH6.
TM5441 sodium purchased from MedChemExpress. Usage Cited in: Kidney Int. 2023 Sep;104(3):508-525. [Abstract]
TM5441 (PAI-1 inhibitor) or vehicle (DMSO) to the previous transwell systems. TM5441 treatment in the podocytes decreased TGFB1 and FN1.
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Sci Adv
Determining sex differences in aortic valve myofibroblast responses to drug combinations identified using a digital medicine platform. [Abstract]2025 Jun 6;11(23):eadu2695. PMID: 40479052
TM5441 sodium purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Jun 6;11(23):eadu2695. [Abstract]
Percent αSMA reduction in male VICs (blue) and female VICs (red) cultured on TCPS with indicated doses of TM5441 (0-1000 μM).
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Eur J Pharmacol
Carbon monoxide attenuates cellular senescence-mediated pulmonary fibrosis via modulating p53/PAI-1 pathway. [Abstract]2024 Jul 26:176843. PMID: 39068977 -
Eur J Pharm Sci
Metabolic activation of TM5441 in vitro and in vivo: Formation of reactive metabolites and human enzymes involved. [Abstract]2020 Feb 15;143:105195. PMID: 31852629 -
Sci Rep
Serpin E1 mediates the induction of renal tubular degeneration and premature senescence upon diabetic insult. [Abstract]2023 Sep 27;13(1):16210. PMID: 37758806
TM5441 sodium purchased from MedChemExpress. Usage Cited in: Sci Rep. 2023 Sep 27;13(1):16210. [Abstract]
Paracrine senescence effects were largely abolished by the addition of the Serpin E1 inhibitor TM5441 (10 μM, pre-incubate for 1 hour) to the conditioned medium.
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Biol Pharm Bull
Arid5a/IL-6/PAI-1 Signaling Is Involved in the Pathogenesis of Lipopolysaccharide-Induced Kidney Injury. [Abstract]2023 Oct 10;46(12):1753-1760. PMID: 38044094 -
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Res Sq
Hypermethylation suppresses microRNA-219a-2 to activate the ALDH1L2/GSH/PAI-1 pathway for fibronectin degradation in renal fibrosis. [Abstract]2023 Jun 5:rs.3.rs-2986934. PMID: 37333081
TM5441 sodium purchased from MedChemExpress. Usage Cited in: Res Sq. 2023 Jun 5:rs.3.rs-2986934. [Abstract]
HEK293 cells with NC or ALDH1L2 siRNA were treated with PAI-1 inhibitor TM5441 and then subjected to TGF-b1 treatment.
Purity & Documentation
References
[1]. Placencio VR, et al. Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity. PLoS One. 2015 Jul 24;10(7):e0133786. [Content Brief]
[2]. Jeong BY, et al. Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model. PLoS One. 2016 Jun 3;11(6):e0157012. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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