Eupaglehnin C
Eupaglehnin C is a germacrane-type sesquiterpenoi. Eupaglehnin C can be isolated from the MeOH extract of Eupatorium glehni (Compositae). Eupaglehnin C has cytotoxic activity against HeLa-S3 cancer cell lines.
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- CAS. Nr.: 476630-49-6
- Formel: C20H26O5
- Molecular Weight:346.42
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Eupaglehnin C inhibits HeLa-S3 with an IC50 value of 2.19 mg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 476630-49-6
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Molecular Weight 346.42
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Formel C20H26O5
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SMILES
C/C=C(CO)\C(O[C@H]1[C@]2([H])[C@](/C=C(CC/C=C(C1)\C)\C)([H])OC(C2=C)=O)=O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Reinheit & Dokumentation
Verweise
[1]. Tori M, et al. Seven germacranolides, eupaglehnins A, B, C, D, E, and F, and 2alpha-acetoxyepitulipinolide from Eupatorium glehni. Chem Pharm Bull (Tokyo). 2002 Sep;50(9):1250-4. [Content Brief]
[2]. Zhang ML, et al. Chemical constituents of plants from the genus Eupatorium. Chem Biodivers. 2008 Jan;5(1):40-55. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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