1. Apoptosis
  2. Apoptosis
  3. F16

F16 is a potent growth inhibitor of the neu-overexpressing cells and also selectively inhibits proliferation of mammary epithelial as well as a variety of mouse mammary tumor and human breast cancer cell lines.

For research use only. We do not sell to patients.

F16 Chemical Structure

F16 Chemical Structure

CAS No. : 36098-33-6

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Solid + Solvent
10 mM * 1 mL in DMSO
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USD 66 In-stock
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10 mM * 1 mL in DMSO USD 66 In-stock
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5 mg USD 38 In-stock
10 mg USD 60 In-stock
25 mg USD 120 In-stock
50 mg USD 216 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

F16 is a potent growth inhibitor of the neu-overexpressing cells and also selectively inhibits proliferation of mammary epithelial as well as a variety of mouse mammary tumor and human breast cancer cell lines. F16 is a mitochondriotoxic compound, and triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell[1][2].

In Vitro

F16 (3 μM; 3 days/7 days) affects growth in several mouse and human cancer cell lines[1].
F16 arrests cell cycle and increases apoptosis in F16-sensitive EpH4-A6 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MDA-MB231, MDA-MB435, MDA-MB436, MDA-MB453, MDA-MB-468, SKBR-3, MCF-7, T47D, ZR-75-1 cells and mouse mammary epithelial cell line NMuMG
Concentration: 3 μM
Incubation Time: 3 days/7 days
Result: Displayed antiproliferative activity against both mouse and human breast cancer cells. The growth of the mouse fibrosarcoma cell lines derived from ras-transgenic mice was not affected.
Clinical Trial
Molecular Weight

362.21

Formula

C16H15IN2

CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

C[N+]1=CC=C(/C=C/C2=CNC3=C2C=CC=C3)C=C1.[I-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (85.59 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 1 mg/mL (2.76 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7608 mL 13.8041 mL 27.6083 mL
5 mM 0.5522 mL 2.7608 mL 5.5217 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 2.7608 mL 13.8041 mL 27.6083 mL 69.0207 mL
DMSO 5 mM 0.5522 mL 2.7608 mL 5.5217 mL 13.8041 mL
10 mM 0.2761 mL 1.3804 mL 2.7608 mL 6.9021 mL
15 mM 0.1841 mL 0.9203 mL 1.8406 mL 4.6014 mL
20 mM 0.1380 mL 0.6902 mL 1.3804 mL 3.4510 mL
25 mM 0.1104 mL 0.5522 mL 1.1043 mL 2.7608 mL
30 mM 0.0920 mL 0.4601 mL 0.9203 mL 2.3007 mL
40 mM 0.0690 mL 0.3451 mL 0.6902 mL 1.7255 mL
50 mM 0.0552 mL 0.2761 mL 0.5522 mL 1.3804 mL
60 mM 0.0460 mL 0.2301 mL 0.4601 mL 1.1503 mL
80 mM 0.0345 mL 0.1726 mL 0.3451 mL 0.8628 mL
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F16 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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