SYL3C aptamer sodium

SYL3C aptamer (various concentrations; 30 min at 37 °C) sodium binds to human breast cancer MDA-MB-231 cells with a K_d of 38 nM and to human gastric cancer Kato III cells with a K_d of 67 nM, exhibiting stronger affinity than the full-length SYL3 aptamer^[1].
SYL3C aptamer (200 nM; 30 min flow cytometry, 40 min confocal imaging) sodium specifically binds to human EpCAM-positive cancer cell lines (MDA-MB-231, Kato III, HT-29, T47D, SW480) and does not bind to human EpCAM-negative cell lines (HEK-293T, U118MG, Ramos)^[1].
SYL3C aptamer (200 nM; 40 min at 4 °C) sodium selectively labels EpCAM-positive human breast cancer MDA-MB-231 cells and human gastric cancer Kato III cells for fluorescence imaging, with no detectable labeling of EpCAM-negative human embryonic kidney HEK-293T cells^[1].
SYL3C aptamer (30 min cell incubation) sodium immobilized on a solid surface captures human gastric cancer Kato III cells with up to 63% efficiency and 80% purity, with minimal non-specific capture of EpCAM-negative Ramos cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.