8-OAc
8-OAc is a potent and selective mitochondrial electron transport chain (ETC) complex I inhibitor. 8-OAc exhibits cytotoxicity against cancer cell lines.
For research use only. We do not sell to patients.
- CAS No.: 2550395-87-2
- Formula: C24H34N2O4S
- Molecular Weight:446.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
8-OAc (5-100 μM; 24 h) could preferentially target cancer cells for the initiation of cell death pathways, while having minimal effects on viability of non-cancer cells. 8-OAc can induce ROS production, leading to cell death in liver cancer cells[1].
8-OAc is able to achieve a mitohormetic effect in C. elegans and prolong longevity in adult worms. 8-OAc requires HSF1 mediate heat shock response (HSR) pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh-7 liver carcinoma cells and BJ fibroblast non-cancer cells
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Concentration:5 μM, 10 μM, 50 μM, 100 μM
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Incubation Time:24 h
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Result:Inhibited Huh-7 and BJ cells with IC50 of 95.97 μM and 248.15 μM, respectively.
Chemical Information
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CAS No. 2550395-87-2
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Molecular Weight 446.60
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Formula C24H34N2O4S
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SMILES
O=C(NCCC(/C=C\C[C@H](OC(C)=O)C(C)(C)C1=NC(C/C=C\CC=C)=CS1)=C)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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