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Cat. No.: HY-178142

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Multi-kinase-IN-7

Multi-kinase-IN-7 is a multikinase inhibitor with IC₅₀s of 2.19, 2.95, 3.59 and 9.31 μM against EGFR, VEGFR2, TrKA and CDK2, respectively. Multi-kinase-IN-7 shows moderate and weaker activity against FAK, AKT1, GSK3β and CDK5 with IC₅₀ values of 6.3, 9.2, 11.7 and 23.4 μM, respectively. Multi-kinase-IN-7 displays broad spectrum antiproliferative potential against NCI cancer cell lines. Multi-kinase-IN-7 induces cell cycle arrest, apoptosis and necrosis. Multi-kinase-IN-7 Inhibitor can be used for the study of breast cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₁₈H₁₃BrN₆
분자량:393.24

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Multi-kinase-IN-7 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

EGFR

2.19 μM (IC₅₀)

VEGFR-2

2.95 μM (IC₅₀)

TrkA

3.59 μM (IC₅₀)

CDK2

9.31 μM (IC₅₀)

CDK5

23.4 μM (IC₅₀)

Akt1

9.2 μM (IC₅₀)

GSK3β

11.7 μM (IC₅₀)

Caspase 3

Bax

Bcl-2

All EGFR Isoforms :

All VEGFR Isoforms :

All Trk Receptor Isoforms :

All CDK Isoforms :

All Akt Isoforms :

All GSK-3 Isoforms :

All Caspase Isoforms :

All Bcl-2 Family Isoforms :

In Vitro

Multi-kinase-IN-7 (Compound 12b) (0.01-100 μM, 24 h) displays broad spectrum anti proliferative potential against NCI cancer cell lines with GI₅₀ mean value of 10.63 μM and exhibits potent antiproliferative activities against all breast cancer lines with GI₅₀ ranges of 4.03-15.3 μM^[1].
Multi-kinase-IN-7 (15.3 μM, 48 h) arrests the cell cycle of MDA-MB-231 cells at the G2/M phase and significantly induces apoptosis (through intrinsic pathway) and necrosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

MDA-MB-231 cells
Concentration:

15.3 μM
Incubation Time:

48 h
Result:

Inhibited proliferation by blocking the G2/M phase.

Apoptosis Analysis^[1]

Cell Line:

MDA-MB-231 cells
Concentration:

15.3 μM
Incubation Time:

48 h
Result:

Significantly induced apoptosis and necrosis, which are the main forms of cell death.
Increased activated Caspase-3 and Bax, and decreased Bcl-2.

Chemical Information

분자량 393.24
화학식 C₁₈H₁₃BrN₆
SMILES

N#CC1=C(N)N2C(NC1C3=CC=C(Br)C=C3)=NC(C4=CC=CC=C4)=N2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Eldeeb AH, et al. Design, synthesis and biological evaluation of triazolo[1,5-a]pyrimidine derivatives as new antiproliferative agents with multikinase inhibitory activity. Bioorg Chem. 2025 Aug 22;165:108899. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Multi-kinase-IN-7

All EGFR Isoforms

All VEGFR Isoforms

All Trk Receptor Isoforms

All CDK Isoforms

All Akt Isoforms

All GSK-3 Isoforms

All Caspase Isoforms

All Bcl-2 Family Isoforms