TrxR-IN-3
TrxR-IN-3 (Compound 2c) is a potent inhibitor of TrxR. TrxR-IN-3 exhibits potent antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and resulted in marked apoptosis by regulating apoptosis-related proteins expressed in the breast cancer cells. TrxR-IN-3 also triggers the formation of autophagosomes and autolysosomes by promoting the expression of LC3-II and Beclin-1 and diminishing the expression of LC3-I and p62 proteins.
For research use only. We do not sell to patients.
- CAS No.: 2445565-58-0
- Formula: C14H11F3O2
- Molecular Weight:268.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.44 μM
Compound: 2c
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Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
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[PMID: 32736231] |
| KB | IC50 |
0.53 μM
Compound: 2c
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Antiproliferative activity against human KB cells after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human KB cells after 72 hrs by sulforhodamine B assay
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[PMID: 32736231] |
| MCF7 | IC50 |
1.04 μM
Compound: 2c
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Antiproliferative activity against human MCF7 cells after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human MCF7 cells after 72 hrs by sulforhodamine B assay
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[PMID: 32736231] |
| MDA-MB-231 | IC50 |
0.59 μM
Compound: 2c
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Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
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[PMID: 32736231] |
Chemical Information
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CAS No. 2445565-58-0
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Molecular Weight 268.23
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Formula C14H11F3O2
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SMILES
O=C1C=CCC/C1=C\C2=CC=C(OC(F)(F)F)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TrxR-IN-3 Related Classifications
HY-146307 Related Classifications
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