2445565-58-0
Chemical Structure
TrxR-IN-3
- CAS No.: 2445565-58-0
- Formula:C14H11F3O2
- Molecular Weight:268.23
IUPAC Name: (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-(2-oxoimidazolidine-1-carboxamido)-2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-oxide
InChIKey: URYRNEUOPCZISV-PKNBQFBNSA-N
SMILES: O=C1C=CCC/C1=C\C2=CC=C(OC(F)(F)F)C=C2
Biological Activity: TrxR-IN-3 is a thioredoxin reductase (TrxR) inhibitor with an IC50 of 0.12 µM in MDA-MB-231 cells. TrxR-IN-3 inhibits TrxR enzyme activity and suppresses TrxR protein expression. TrxR-IN-3 induces reactive oxygen species (ROS) accumulation, apoptosis, and autophagy. TrxR-IN-3 modulates apoptosis-related proteins by decreasing anti-apoptotic protein levels and increasing caspase cleavage. TrxR-IN-3 modulates autophagy-related proteins by increasing autophagy markers and reducing autophagy substrate proteins. TrxR-IN-3 can be used for breast cancer research[1].
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TrxR-IN-3 | TrxR-IN-3 is a thioredoxin reductase (TrxR) inhibitor with an IC50 of 0.12 µM in MDA-MB-231 cells. TrxR-IN-3 inhibits TrxR enzyme activity and suppresses TrxR protein expression. TrxR-IN-3 induces reactive oxygen species (ROS) accumulation, apoptosis, and autophagy. TrxR-IN-3 modulates apoptosis-related proteins by decreasing anti-apoptotic protein levels and increasing caspase cleavage. TrxR-IN-3 modulates autophagy-related proteins by increasing autophagy markers and reducing autophagy substrate proteins. TrxR-IN-3 can be used for breast cancer research. | |||||||||||||||||||||
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