2445565-58-0
Chemical Structure
TrxR-IN-3
- CAS No.: 2445565-58-0
- Formula:C14H11F3O2
- Molecular Weight:268.23
IUPAC Name: (E)-6-(4-(trifluoromethoxy)benzylidene)cyclohex-2-en-1-one
InChIKey: URYRNEUOPCZISV-PKNBQFBNSA-N
SMILES: O=C1C=CCC/C1=C\C2=CC=C(OC(F)(F)F)C=C2
Biological Activity: TrxR-IN-3 (Compound 2c) is a potent inhibitor of TrxR. TrxR-IN-3 exhibits potent antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and resulted in marked apoptosis by regulating apoptosis-related proteins expressed in the breast cancer cells. TrxR-IN-3 also triggers the formation of autophagosomes and autolysosomes by promoting the expression of LC3-II and Beclin-1 and diminishing the expression of LC3-I and p62 proteins[1].
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TrxR-IN-3 | TrxR-IN-3 (Compound 2c) is a potent inhibitor of TrxR. TrxR-IN-3 exhibits potent antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and resulted in marked apoptosis by regulating apoptosis-related proteins expressed in the breast cancer cells. TrxR-IN-3 also triggers the formation of autophagosomes and autolysosomes by promoting the expression of LC3-II and Beclin-1 and diminishing the expression of LC3-I and p62 proteins. | |||||||||||||||||||||
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