2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Caspase Reactive Oxygen Species (ROS) Apoptosis
  4. Dicatenarin

Dicatenarin is a caspase‑3 activator with growth‑inhibitory activity against human cancer cells. Dicatenarin increases caspase‑3 activity, induces intracellular ROS generation, and activates the mitochondrial‑mediated apoptotic pathway. Dicatenarin exerts growth‑inhibitory effects against a panel of human cancer cell lines. Dicatenarin can be used in research on pancreatic cancer, lung cancer, colon cancer, breast cancer, prostate cancer, and ovarian cancer.

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Dicatenarin

Dicatenarin Chemical Structure

CAS No. : 1065-08-3

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Dicatenarin Related Antibodies

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Description

Dicatenarin is a caspase‑3 activator with growth‑inhibitory activity against human cancer cells. Dicatenarin increases caspase‑3 activity, induces intracellular ROS generation, and activates the mitochondrial‑mediated apoptotic pathway. Dicatenarin exerts growth‑inhibitory effects against a panel of human cancer cell lines. Dicatenarin can be used in research on pancreatic cancer, lung cancer, colon cancer, breast cancer, prostate cancer, and ovarian cancer[1][2].

IC50 & Target[1]

Caspase-3

 

In Vitro

Dicatenarin (1-100 µg/mL; 48 h) potently inhibits growth of human lung (A549), pancreatic (MIA PaCa-2), colon (HCT-116), breast (T47D), prostate (PC-3), and ovarian (OVCAR-3) cancer cell lines in vitro, with the lowest IC50 of 12 µg/mL against MIA PaCa-2 cells[1][2].
induces both early and late-stage apoptosisDicatenarin (5-20 µg/mL; 48 h) induces concentration-dependent apoptotic nuclear morphological changes in human pancreatic cancer (MIA PaCa-2) cells[1].
Dicatenarin (20 µg/mL; 48 h) induces both early and late-stage apoptosis in human pancreatic cancer (MIA PaCa-2) cells[1].
Dicatenarin (5-20 µg/mL; 48 h) induces concentration-dependent intracellular ROS generation in human pancreatic cancer (MIA PaCa-2) cells[1].
Dicatenarin (5-20 µg/mL; 48 h) induces concentration-dependent loss of mitochondrial transmembrane potential in human pancreatic cancer (MIA PaCa-2) cells[1].
Dicatenarin (5-20 µg/mL; 48 h) induces concentration-dependent release of cytochrome c from mitochondria to the cytosol in human pancreatic cancer (MIA PaCa-2) cells[1].
Dicatenarin (5-20 µg/mL; 48 h) induces concentration-dependent activation of caspase-3 in human pancreatic cancer (MIA PaCa-2) cells[1].
Dicatenarin (5-20 µg/mL; 7 days) potently inhibits clonogenic survival of human pancreatic cancer (MIA PaCa-2) cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dicatenarin Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: A549, MIA PaCa-2, HCT-116, T47D, PC-3, OVCAR-3
Concentration: 1, 10, 30, 50, 100 µg/mL
Incubation Time: 48 h
Result: Exhibited cytotoxicity against all tested cell lines, with IC50 values of 23 µg/mL (A549), 12 µg/mL (MIA PaCa-2), 17 µg/mL (HCT-116), 29 µg/mL (T47D), 35 µg/mL (PC-3), and 26 µg/mL (OVCAR-3).

Apoptosis Analysis[1]

Cell Line: MIA PaCa-2
Concentration: 20 µg/mL
Incubation Time: 48 h
Result: Resulted in significant phosphatidylserine externalization (early apoptosis) and late-stage apoptotic/necrotic PI-positive staining, with a higher proportion of annexin V-positive cells compared to skyrin treatment.

Immunofluorescence[1]

Cell Line: MIA PaCa-2
Concentration: 5, 10, 20 µg/mL
Incubation Time: 48 h
Result: Induced concentration-dependent release of cytochrome c from mitochondria into the cytosol.
Showed minimal release at 5 µg/mL, moderate release at 10 µg/mL, prominent, diffuse cytosolic cytochrome c staining at 20 µg/mL, indicating complete mitochondrial outer membrane permeabilization.

Cell Proliferation Assay[1]

Cell Line: MIA PaCa-2
Concentration: 5, 10, 20 µg/mL
Incubation Time: 7 days
Result: Caused concentration-dependent inhibition of colony formation.
Reduced colony number to ~460 (from ~550 in controls) at 5 µg/mL, to ~210 at 10 µg/mL, to ~50 at 20 µg/mL, representing a 91% reduction in colony formation at the highest concentration.
Molecular Weight

570.46

Formula

C30H18O12
CAS No.
SMILES

O=C1C2=C(C=C(C)C(O)=C2C(C3=C1C(O)=CC(O)=C3C(C(O)=CC(O)=C4C(C5=C(C=C(C)C(O)=C56)O)=O)=C4C6=O)=O)O
Structure Classification
Initial Source

Penicillium pinophilum
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dicatenarin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dicatenarin1065-08-3CaspaseReactive Oxygen Species (ROS)ApoptosisNCI60/ATCC panelMIA PaCa-2caspase-3A549mitochondrial-mediated apoptotic pathwayshuman pancreatic cancer cellsmitochondrial transmembrane potentialhuman cancer cellsHCT-116reactive oxygen speciesInhibitorinhibitorinhibit

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