1065-08-3
Chemical Structure
Dicatenarin
- CAS No.: 1065-08-3
- Formula:C30H18O12
- Molecular Weight:570.46
InChIKey: UJQQRKKOXCGWSR-UHFFFAOYSA-N
SMILES: O=C1C2=C(C=C(C)C(O)=C2C(C3=C1C(O)=CC(O)=C3C(C(O)=CC(O)=C4C(C5=C(C=C(C)C(O)=C56)O)=O)=C4C6=O)=O)O
Biological Activity: Dicatenarin is a caspase‑3 activator with growth‑inhibitory activity against human cancer cells. Dicatenarin increases caspase‑3 activity, induces intracellular ROS generation, and activates the mitochondrial‑mediated apoptotic pathway. Dicatenarin exerts growth‑inhibitory effects against a panel of human cancer cell lines. Dicatenarin can be used in research on pancreatic cancer, lung cancer, colon cancer, breast cancer, prostate cancer, and ovarian cancer[1][2].
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Dicatenarin | Dicatenarin is a caspase‑3 activator with growth‑inhibitory activity against human cancer cells. Dicatenarin increases caspase‑3 activity, induces intracellular ROS generation, and activates the mitochondrial‑mediated apoptotic pathway. Dicatenarin exerts growth‑inhibitory effects against a panel of human cancer cell lines. Dicatenarin can be used in research on pancreatic cancer, lung cancer, colon cancer, breast cancer, prostate cancer, and ovarian cancer. | |||||||||||||||||||||
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References
- [1]. Koul M, et al. Secondary Metabolites from Endophytic Fungus Penicillium pinophilum Induce ROS-Mediated Apoptosis through Mitochondrial Pathway in Pancreatic Cancer Cells. Planta Med. 2016;82(4):344-355. [Content Brief]
- [2]. Lee D, et al. 4,6'-Anhydrooxysporidinone from Fusarium lateritium SSF2 Induces Autophagic and Apoptosis Cell Death in MCF-7 Breast Cancer Cells. Biomolecules. 2021 Jun 11;11(6):869.
