2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Tyrosine kinase-IN-7

Tyrosine kinase-IN-7 (compound 13h) is an inhibitor of the tyrosine kinase EGFR. The IC50s for inhibiting EGFR(WT) and EGFR(T790M) are 0.630 μM and 0.956 μM respectively. Tyrosine kinase-IN-7 has antitumor activity against four cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC50s of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively.

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Tyrosine kinase-IN-7 Chemical Structure

Tyrosine kinase-IN-7 Chemical Structure

CAS No. : 345615-74-9

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Based on 1 publication(s) in Google Scholar

Tyrosine kinase-IN-7 Related Antibodies

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Description

Tyrosine kinase-IN-7 (compound 13h) is an inhibitor of the tyrosine kinase EGFR. The IC50s for inhibiting EGFR(WT) and EGFR(T790M) are 0.630 μM and 0.956 μM respectively. Tyrosine kinase-IN-7 has antitumor activity against four cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC50s of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively[1].

IC50 & Target

IC50: 0.630 μM (EGFRWT), 0.956 μM (EGFRT790M)[1]
Molecular Weight

297.37

Formula

C16H15N3OS
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

OC1=CC=C(NC2=C3C(CCCC4)=C4SC3=NC=N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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Tyrosine kinase-IN-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyrosine kinase-IN-7345615-74-9EGFREpidermal growth factor receptorErbB-1HER1AnticancerApoptosisDockingEGFR(T790M)EGFR(WT)EGFR-TKHER2Thieno[2,3-d]pyrimidineInhibitorinhibitorinhibit

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