Tyrosine kinase-IN-7
Based on 1 Customer Validation
Tyrosine kinase-IN-7 (compound 13h) is an inhibitor of the tyrosine kinase EGFR. The IC50s for inhibiting EGFR(WT) and EGFR(T790M) are 0.630 μM and 0.956 μM respectively. Tyrosine kinase-IN-7 has antitumor activity against four cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC50s of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively.
For research use only. We do not sell to patients.
- Purity: 99.25%
- CAS No.: 345615-74-9
- Formula: C16H15N3OS
- Molecular Weight:297.37
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Posttranslational Modification Library
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All EGFR Isoforms
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Biological Activity
IC50: 0.630 μM (EGFRWT), 0.956 μM (EGFRT790M)[1]
Chemical Information
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CAS No. 345615-74-9
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Appearance Solid
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Molecular Weight 297.37
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Formula C16H15N3OS
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Color Off-white to light brown
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SMILES
OC1=CC=C(NC2=C3C(CCCC4)=C4SC3=NC=N2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (336.28 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3628 mL | 16.8141 mL | 33.6281 mL | 84.0704 mL |
| 5 mM | 0.6726 mL | 3.3628 mL | 6.7256 mL | 16.8141 mL | |
| 10 mM | 0.3363 mL | 1.6814 mL | 3.3628 mL | 8.4070 mL | |
| 15 mM | 0.2242 mL | 1.1209 mL | 2.2419 mL | 5.6047 mL | |
| 20 mM | 0.1681 mL | 0.8407 mL | 1.6814 mL | 4.2035 mL | |
| 25 mM | 0.1345 mL | 0.6726 mL | 1.3451 mL | 3.3628 mL | |
| 30 mM | 0.1121 mL | 0.5605 mL | 1.1209 mL | 2.8023 mL | |
| 40 mM | 0.0841 mL | 0.4204 mL | 0.8407 mL | 2.1018 mL | |
| 50 mM | 0.0673 mL | 0.3363 mL | 0.6726 mL | 1.6814 mL | |
| 60 mM | 0.0560 mL | 0.2802 mL | 0.5605 mL | 1.4012 mL | |
| 80 mM | 0.0420 mL | 0.2102 mL | 0.4204 mL | 1.0509 mL | |
| 100 mM | 0.0336 mL | 0.1681 mL | 0.3363 mL | 0.8407 mL |
Tyrosine kinase-IN-7 Related Classifications
HY-156912 Related Classifications
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