345615-74-9
345615-74-9
Chemical Structure
Tyrosine kinase-IN-7
- CAS 番号: 345615-74-9
- Formula:C16H15N3OS
- Molecular Weight:297.37
InChIKey: BTIBWAOCLJARHL-UHFFFAOYSA-N
SMILES: OC1=CC=C(NC2=C3C(CCCC4)=C4SC3=NC=N2)C=C1
Biological Activity: Tyrosine kinase-IN-7 (compound 13h) is an inhibitor of the tyrosine kinase EGFR. The IC50s for inhibiting EGFR(WT) and EGFR(T790M) are 0.630 μM and 0.956 μM respectively. Tyrosine kinase-IN-7 has antitumor activity against four cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC50s of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively[1].
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Tyrosine kinase-IN-7 | 99.25% | Tyrosine kinase-IN-7 (compound 13h) is an inhibitor of the tyrosine kinase EGFR. The IC50s for inhibiting EGFR(WT) and EGFR(T790M) are 0.630 μM and 0.956 μM respectively. Tyrosine kinase-IN-7 has antitumor activity against four cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC50s of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively. | ||||||||||||||||||||
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