2. Protein Tyrosine Kinase/RTK PROTAC
  3. FAK Ligands for Target Protein for PROTAC
  4. FAK-IN-31

FAK-IN-31 is a FAK inhibitor with antiproliferative activity against a variety of cancer cell lines. FAK-IN-31 serves as a PROTAC target protein ligand for the development of FAK-targeted PROTAC degrader heads, such as PROTAC FAK degrader 5 (HY-183768). FAK-IN-31 can be used in the research of colorectal cancer, pancreatic cancer, breast cancer, hepatocellular carcinoma and lung cancer.

For research use only. We do not sell to patients.

FAK-IN-31

FAK-IN-31 Chemical Structure

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FAK-IN-31 Related Antibodies

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Description

FAK-IN-31 is a FAK inhibitor with antiproliferative activity against a variety of cancer cell lines. FAK-IN-31 serves as a PROTAC target protein ligand for the development of FAK-targeted PROTAC degrader heads, such as PROTAC FAK degrader 5 (HY-183768). FAK-IN-31 can be used in the research of colorectal cancer, pancreatic cancer, breast cancer, hepatocellular carcinoma and lung cancer[1].

In Vitro

FAK-IN-31 (compound 5c) (72 h) potently inhibits the proliferation of multiple human cancer cell lines, including colorectal cancer HCT-15 and HCT116 cells with IC50 values of 0.65 μM and 1.12 μM, respectively, and exhibits relatively low cytotoxicity toward normal human L02 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FAK-IN-31 Related Antibodies
Molecular Weight

442.39

Formula

C22H17F3N4O3
SMILES

O=C(NCC#C)C1=CC=C(NC2=NC=C(C(F)(F)F)C(OC3=CC=CC=C3OC)=N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FAK-IN-31 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAK-IN-31FAKLigands for Target Protein for PROTACPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseTarget Protein-binding MoietyHCT116lung cancerbreast cancerL02colorectal cancerpancreatic cancerHCT-15hepatocellular carcinomaInhibitorinhibitorinhibit

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HY-183769
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