FAK-IN-31
FAK-IN-31 is a FAK inhibitor with antiproliferative activity against a variety of cancer cell lines. FAK-IN-31 serves as a PROTAC target protein ligand for the development of FAK-targeted PROTAC degrader heads, such as PROTAC FAK degrader 5 (HY-183768). FAK-IN-31 can be used in the research of colorectal cancer, pancreatic cancer, breast cancer, hepatocellular carcinoma and lung cancer.
For research use only. We do not sell to patients.
- Formula: C22H17F3N4O3
- Molecular Weight:442.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
FAK-IN-31 (compound 5c) (72 h) potently inhibits the proliferation of multiple human cancer cell lines, including colorectal cancer HCT-15 and HCT116 cells with IC50 values of 0.65 μM and 1.12 μM, respectively, and exhibits relatively low cytotoxicity toward normal human L02 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 442.39
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Formula C22H17F3N4O3
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SMILES
O=C(NCC#C)C1=CC=C(NC2=NC=C(C(F)(F)F)C(OC3=CC=CC=C3OC)=N2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FAK-IN-31 Related Classifications
HY-183769 Related Classifications
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