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KX2-391 Mesylate

HY-10340B

(KX01 Mesylate)

KX2-391 Mesylate

KX2-391 Mesylate Chemical Structure

is a synthetic, orally bioavailable inhibitor of Src kinase and tubulin polymerization, with IC50 of 20 nM for Scr kinase autophosphorylation.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $81 In-stock
5 mg $70 In-stock
10 mg $120 In-stock
50 mg $470 In-stock
100 mg $800 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €79 In-stock
5 mg €69 In-stock
10 mg €118 In-stock
50 mg €461 In-stock
100 mg €784 In-stock
200 mg Get quote
500 mg Get quote

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Product name: KX2-391 Mesylate
Cat. No.: HY-10340B

KX2-391 Mesylate Data Sheet

Related Compound Libraries

Biological Activity of KX2-391 Mesylate

is a synthetic, orally bioavailable inhibitor of Src kinase and tubulin polymerization, with IC50 of 20 nM for Scr kinase autophosphorylation.
IC50: 20 nM (Scr kinase)
in vitro: KX2-391 has been shown to potently inhibit Src-catalyzed trans-phosphorylation of focal adhesion kinase (FAK), Shc, paxillin, and Src kinase autophosphorylation with an IC50 of approximately 20 nM. It also induces p53 expression and stimulates caspase-3 and PARP cleavage in vitro, leading to tumor cell apoptosis. KX2-391 is potent against a broad range of solid tumor cell types as well as many leukemia subtypes, including those resistant to imatinib and/or dasatinib. It is highly selective without effects on PDGFR, EGFR, JAK1, JAK2, Lck and ZAP70. KX2-391 targets the substrate binding pocket of Src and had more broad spectrum activity and higher potency than dasatinib[1].
in vovo: KX2-391 demonstrates potent antineoplastic activity across a wide spectrum of tumor cell lines (including several prostate cancer cell lines) and inhibits primary tumor growth as well as metastasis in an orthotopic prostate cancer mouse model[2].
 

Chemical Information

M.Wt 527.63 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₂₇H₃₃N₃O₆S
CAS No 1080645-95-9
Solvent & Solubility

DMSO: ≥ 57 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.8953 mL 9.4763 mL 18.9527 mL
5 mM 0.3791 mL 1.8953 mL 3.7905 mL
10 mM 0.1895 mL 0.9476 mL 1.8953 mL

References on KX2-391 Mesylate

Other Forms

Inhibitor Kit

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