1. Protein Tyrosine Kinase/RTK
    Cell Cycle/DNA Damage
    Cytoskeleton
  2. Src
    Microtubule/Tubulin

KX2-391 Mesylate (Synonyms: KX01 Mesylate)

Cat. No.: HY-10340B Purity: 99.97%
Handling Instructions

KX2-391 Mesylate is a synthetic, orally bioavailable inhibitor of Src kinase and tubulin polymerization.

For research use only. We do not sell to patients.
KX2-391 Mesylate Chemical Structure

KX2-391 Mesylate Chemical Structure

CAS No. : 1080645-95-9

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Free sample   Apply now  
10 mM * 1 mL in DMSO $81 In-stock
5 mg $70 In-stock
10 mg $120 In-stock
50 mg $470 In-stock
100 mg $800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

KX2-391 Mesylate is a synthetic, orally bioavailable inhibitor of Src kinase and tubulin polymerization.

In Vitro

KX2-391 has been shown to potently inhibit Src-catalyzed trans-phosphorylation of focal adhesion kinase (FAK), Shc, paxillin, and Src kinase autophosphorylation with an IC50 of approximately 20 nM. It also induces p53 expression and stimulates caspase-3 and PARP cleavage in vitro, leading to tumor cell apoptosis. KX2-391 is potent against a broad range of solid tumor cell types as well as many leukemia subtypes, including those resistant to imatinib and/or dasatinib. It is highly selective without effects on PDGFR, EGFR, JAK1, JAK2, Lck and ZAP70. KX2-391 targets the substrate binding pocket of Src and had more broad spectrum activity and higher potency than dasatinib[1].

In Vivo

KX2-391 demonstrates potent antineoplastic activity across a wide spectrum of tumor cell lines (including several prostate cancer cell lines) and inhibits primary tumor growth as well as metastasis in an orthotopic prostate cancer mouse model[2].

References
M.Wt

527.63

Formula

C₂₇H₃₃N₃O₆S

CAS No.

1080645-95-9

Storage

-20°C, protect from light, stored under nitrogen

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 57 mg/mL

Purity: 99.97%

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Product Name:
KX2-391 Mesylate
Cat. No.:
HY-10340B
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