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Cat. No.: HY-147802

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EGFR-IN-59

EGFR-IN-59 (Compound 8c) is a EGFR inhibitor (IC₅₀=190 nM) and apoptosis inducer. EGFR-IN-59 exhibits cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) with IC₅₀s of 8.62 and 52.6 µM, respectively. EGFR-IN-59 can be used for the research of various cancers such as non-small cell lung cancer (NSCLC), head and neck cancer, breast cancer and colorectal cancer.

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CAS No.: 2529891-44-7
Formule: C₂₇H₂₃N₅O₄S
Masse moléculaire:513.57

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

EGFR-IN-59 Chemical Structure

CAS No.: 2529891-44-7

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

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Activité biologique

Description

Voir tous les produits spécifiques à Isoform EGFR :

In Vitro

EGFR-IN-59 (Compound 8c; 0-65.5 µM; 48 hours) shows cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

A549; WI38 cells
Concentration:

0-65.5 µM
Incubation Time:

48 hours
Result:

Showed potent cytotoxicity against A549 cell line (IC₅₀=8.62 µM), and mild to moderate toxicity against WI38 (IC₅₀=52.6 µM).

Chemical Information

CAS No. 2529891-44-7
Masse moléculaire 513.57
Formule C₂₇H₂₃N₅O₄S
SMILES

O=S(C1=CC=C(NC2=C3C=CC=CC3=NC(/C=C/C4=CC=C(OC)C=C4)=N2)C=C1)(NC5=NOC(C)=C5)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Noha H Amin, et al. Design, synthesis and molecular modeling studies of 2-styrylquinazoline derivatives as EGFR inhibitors and apoptosis inducers. Bioorg Chem. 2020 Dec;105:104358. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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EGFR-IN-59

Voir tous les produits spécifiques à Isoform EGFR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

EGFR-IN-59 Related Classifications

HY-147802 Related Classifications