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United States

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Cat. No.: HY-147802

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EGFR-IN-59

EGFR-IN-59 (Compound 8c) is a EGFR inhibitor (IC₅₀=190 nM) and apoptosis inducer. EGFR-IN-59 exhibits cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) with IC₅₀s of 8.62 and 52.6 µM, respectively. EGFR-IN-59 can be used for the research of various cancers such as non-small cell lung cancer (NSCLC), head and neck cancer, breast cancer and colorectal cancer.

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CAS No.: 2529891-44-7
화학식: C₂₇H₂₃N₅O₄S
분자량:513.57

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

EGFR-IN-59 Chemical Structure

CAS No.: 2529891-44-7

Amount: USD 0.00

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All EGFR Isoforms :

In Vitro

EGFR-IN-59 (Compound 8c; 0-65.5 µM; 48 hours) shows cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

A549; WI38 cells
Concentration:

0-65.5 µM
Incubation Time:

48 hours
Result:

Showed potent cytotoxicity against A549 cell line (IC₅₀=8.62 µM), and mild to moderate toxicity against WI38 (IC₅₀=52.6 µM).

Chemical Information

CAS No. 2529891-44-7
분자량 513.57
화학식 C₂₇H₂₃N₅O₄S
SMILES

O=S(C1=CC=C(NC2=C3C=CC=CC3=NC(/C=C/C4=CC=C(OC)C=C4)=N2)C=C1)(NC5=NOC(C)=C5)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Noha H Amin, et al. Design, synthesis and molecular modeling studies of 2-styrylquinazoline derivatives as EGFR inhibitors and apoptosis inducers. Bioorg Chem. 2020 Dec;105:104358. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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