2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. EGFR-IN-59

EGFR-IN-59 (Compound 8c) is a EGFR inhibitor (IC50=190 nM) and apoptosis inducer. EGFR-IN-59 exhibits cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) with IC50s of 8.62 and 52.6 µM, respectively. EGFR-IN-59 can be used for the research of various cancers such as non-small cell lung cancer (NSCLC), head and neck cancer, breast cancer and colorectal cancer.

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EGFR-IN-59 Chemical Structure

EGFR-IN-59 Chemical Structure

CAS No. : 2529891-44-7

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EGFR-IN-59 Related Antibodies

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Description

EGFR-IN-59 (Compound 8c) is a EGFR inhibitor (IC50=190 nM) and apoptosis inducer. EGFR-IN-59 exhibits cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) with IC50s of 8.62 and 52.6 µM, respectively. EGFR-IN-59 can be used for the research of various cancers such as non-small cell lung cancer (NSCLC), head and neck cancer, breast cancer and colorectal cancer[1].

In Vitro

EGFR-IN-59 (Compound 8c; 0-65.5 µM; 48 hours) shows cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-59 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: A549; WI38 cells
Concentration: 0-65.5 µM
Incubation Time: 48 hours
Result: Showed potent cytotoxicity against A549 cell line (IC50=8.62 µM), and mild to moderate toxicity against WI38 (IC50=52.6 µM).
Molecular Weight

513.57

Formula

C27H23N5O4S
CAS No.
SMILES

O=S(C1=CC=C(NC2=C3C=CC=CC3=NC(/C=C/C4=CC=C(OC)C=C4)=N2)C=C1)(NC5=NOC(C)=C5)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
References
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EGFR-IN-59 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-592529891-44-7EGFRApoptosisEpidermal growth factor receptorErbB-1HER1apoptosisA549normal lung fibroblastsWI38non-small cell lung cancerNSCLChead and neck cancerbreast cancer and colorectal cancerAntitumorEGFR inhibitionInhibitorinhibitorinhibit

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