EGFR-IN-59
EGFR-IN-59 (Compound 8c) is a EGFR inhibitor (IC50=190 nM) and apoptosis inducer. EGFR-IN-59 exhibits cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) with IC50s of 8.62 and 52.6 µM, respectively. EGFR-IN-59 can be used for the research of various cancers such as non-small cell lung cancer (NSCLC), head and neck cancer, breast cancer and colorectal cancer.
For research use only. We do not sell to patients.
- CAS No.: 2529891-44-7
- Formula: C27H23N5O4S
- Molecular Weight:513.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
EGFR-IN-59 (Compound 8c; 0-65.5 µM; 48 hours) shows cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549; WI38 cells
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Concentration:0-65.5 µM
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Incubation Time:48 hours
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Result:Showed potent cytotoxicity against A549 cell line (IC50=8.62 µM), and mild to moderate toxicity against WI38 (IC50=52.6 µM).
Chemical Information
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CAS No. 2529891-44-7
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Molecular Weight 513.57
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Formula C27H23N5O4S
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SMILES
O=S(C1=CC=C(NC2=C3C=CC=CC3=NC(/C=C/C4=CC=C(OC)C=C4)=N2)C=C1)(NC5=NOC(C)=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-59 Related Classifications
HY-147802 Related Classifications
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